Pfizer, Bristol finalize deal on metabolic drugs

Mon Aug 27, 2007 8:34am EDT

NEW YORK Aug 27 (Reuters) - Pfizer Inc. (PFE.N) and Bristol-Myers Squibb Co. (BMY.N) said on Monday they finalized an agreement reached in April, under which the drugmakers will research, develop and sell a class of medicines called DGAT-1 inhibitors.

The compounds could potentially treat metabolic disorders such as obesity and diabetes, the companies said. Pfizer had already discovered some such compounds in pre-clinical research, meaning early-stage studies not yet involving human subjects.

The partnership also includes DGAT-1 inhibitors that Pfizer licensed last year from German drugmaker Bayer AG BAYG.DE, including a pre-clinical compound known as PF-04415060, or BAY 74-4113.

As previously announced, Pfizer will be responsible for all early-stage studies under the Bristol-Myers deal, while the companies will jointly conduct Phase III -- or late-stage -- trials.

The companies said the compounds are designed to block DGAT-1, an enzyme that plays a big role in creation of blood fats called triglycerides which at high levels can make people more prone to diabetes and related problems.

((Reporting by Ransdell Pierson; Editing by Derek Caney; Reuters Messaging: ransdell.pierson.reuters.com@reuters.net; 646-223-6034; ransdell.pierson@reuters.com)) Keywords: PFIZER BRISTOLMYERS/

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