ISK First to Implement LPS-Flex Mobile Knee in United States

NEW YORK--(Business Wire)--The surgeons of The Insall Scott Kelly(R) Institute (ISK) for
Orthopaedics and Sports Medicine today announced that Dr. Giles R.
Scuderi surgically implanted the first NexGen LPS-Flex mobile bearing
knee in the United States, Thursday at Franklin Hospital in Valley
Stream, New York.

Dr. Giles R. Scuderi, a director of ISK, was one of the few
designers working on this latest product from Zimmer Holdings
Incorporated and the first in the country to implant this new device
that was approved by the Food and Drug Administration in mid-December.

"The design of this mobile bearing knee is especially good for
athletes or very active adults with arthritic knees," said Dr.
Scuderi. "It both flexes and rotates the knee for better motion and a
more natural feel. If you are active with an arthritic knee, than this
is the knee for you."

The investigative device exemption for the NexGen LPS-Flex mobile
bearing knee was approved and used in clinical trials within the
United States beginning five years ago. Dr. Scuderi was one of the
original consultants and investigating surgeons with the design team,
as well as one of the instructors for the surgical technique.

Ron Hamilton of Port Jefferson, New York, was a patient of Dr.
Scuderi's who participated in the clinical trial in July 2002.
Hamilton, now in his 70's, continues to teach personal fitness, take
two spin classes per week and mountain bike. "Five-and-a-half years
ago, my knee was slowly collapsing, so Dr. Scuderi suggested the
mobile-bearing knee," said Hamilton. "I went for it and was quickly
able to get back to my first love, which is conditioning. I have not
had one problem from my surgery and feel more in shape than ever
before."

The NexGen knee system was designed for use with minimally
invasive procedures and intended for use in patients who are
undergoing total knee replacement. The device supports slight rotation
of the knee implant consistent with the patient's movement of the
joint. For an already flexible patient, the knee joint can safely flex
up to 155 degrees of weight bearing active flexion when used in
cooperation with the LPS-Flex femoral component. According to Dr.
Scuderi, "Mobility with flexibility" is the mantra for this implant
design. Most of the knee implants available today are only capable of
flexion to 120 degrees.

The NexGen LPS-Flex mobile knee was launched in Europe in 1999,
and has also been selling in both Australia and Japan. Broad
availability is soon expected throughout the United States.

ABOUT ISK

The Insall Scott Kelly(R) Institute is a full service orthopaedic
center, comprised of a team of world-recognized orthopaedic surgeons,
dedicated to serving the unique needs of the orthopaedic patient.
Created in 1991 by Dr. John Insall, ISK is a specialized center which
focuses on the treatment of orthopaedic and sports related ailments.
ISK now offers three convenient locations in New York, including
Garden City, Bay Shore and Manhattan. Visit the ISK website at
www.iskinstitute.com for more information.

Scott Cooper Associates
Lauren Sklarin, 631-249-9700 x219
lauren@scottcooper.com

Copyright Business Wire 2008