Protherics PLC announces - Holding(s) in Company

CHESHIRE, UK, Jan 22 (MARKET WIRE) --

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 22 January 2008 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 21 January 2008, in accordance with the
Transparency Obligations Directive, a notification of interest in the ordinary
share capital of the Company was received from AXA Investment Managers UK
Limited on behalf of AXA S.A. and its Group Companies ("AXA"). Details of the
notification are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

A disposal of voting rights X

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the AXA S.A., 25 Avenue Matignon,
75008 Paris and its
notification obligation: group of
companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which 17 January
2008
the threshold is crossed or reached if
different):

5. Date on which issuer notified: 18 January
2008

6. Threshold(s) that is/are crossed or reached: 13%

7. Notified details:

A: Voting rights attached to shares
Class/type of Situation previous to Resulting situation after the
triggering transaction
shares the Triggering
transaction

if possible using Number of Number of Number of Number of voting rights
% of voting rights
the ISIN CODE Shares Voting shares
Rights Direct Direct Indirect
Direct Indirect

0702920 49,639,830 49,639,830 741,666 741,666
43,053,507 0.22% 12.66%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial Expiration date Exercise/ Conversion Number of voting
rights % of voting rights
instrument Period/ Date that may be
acquired if
the instrument is
exercised/
converted.

Total (A+B)

Number of voting rights % of voting rights

43,795,173 12.87%

8. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are
effectively held, if applicable :

Name of Company/Fund Number of Shares %
of issued share capital

AXA UK Investment Co ICVC 546,090
0.16052
UK Smaller Companies Fund
Indirect

Sun Life Pensions Management Ltd 25,000
0.00735
Direct

Sun Life Unit Assurance Ltd 53,913
0.01585
FTSE All Share Tracker Life
Direct

Sun Life Pensions Management 294,874
0.08668
FTSE All Share Tracker Pension
Direct

AXA Framlington 750,000
0.22046
SEI UK Equity
Indirect

AXA Framlington 1,600,000
0.47031
St James Place Exempt (Pens) Fund
Indirect

AXA Framlington 1,800,000
0.52910
St James Place Net (Life) Fund
Indirect

AXA Framlington 400,000
0.11758
St James Place Offshore Fund
Indirect

AXA Framlington 600,000
0.17637
Daimler Chrysler
Indirect

AXA Framlington 3,120,333
0.91720
Throgmorton Trust
Indirect

AXA Framlington 15,013,453
4.41308
UK Selet Ops
Indirect

AXA Framlington 13,753,131
4.04262
Equity Income
Indirect

AXA Framlington 2,000,000
0.58788
Managed Balanced
Indirect

AXA Framlington 1,500,000
0.44091
UK Smaller Companies
Indirect

AXA Framlington 500,000
0.14697
BAE Systems Pensions Fund CIF Trustees
Indirect

AXA Framlington 220,000
0.06467
BAE Systems 2000 Pensions Fund
Indirect

Framlington onshore private clients 975,500
0.28674
Indirect

Axa Sun Life With Profits Passive 226,817
0.06667
Direct

Axa Sun Life With Profits Passive 141,062
0.04146
Direct

AXA Framlington 275,000
0.08083
St James Place Internal Equity & Income UT
Indirect

Total Direct 741,666
0.21801
Total Indirect 43,053,507
12.65523

TOTAL 43,795,173
12.87324

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting
rights:

12. Additional information:

| Ends |

For further information please contact:

Protherics
Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510
Julie Vickers, Company Secretary +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt +1 212 850 5600

Or visit www.protherics.com

This information is provided by RNS
The company news service from the London Stock Exchange

Copyright 2008, Market Wire, All rights reserved.

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