Nu Skin Scientists Correlate the Appearance of Aging With arNOX Free Radical Generator

Nu Skin Scientists Correlate the Appearance of Aging With arNOX Free Radical
Generator
Study Subjects with Decreased Enzyme Activity Appear Years Younger

PROVO, Utah, Oct. 13 /PRNewswire-FirstCall/ -- Scientists from Nu Skin
Enterprises Inc. (NYSE: NUS) presented the results of a breakthrough study at
the 25th International Federation of Societies of Cosmetic Chemists Congress
(IFSCC) in Barcelona revealing a correlation between levels of a newly
identified age-related enzyme, arNOX, and a person's appearance. The study,
conducted at Stanford University, demonstrated that women with higher activity
levels of arNOX appeared an average of seven years older than their
chronological age, while women with decreased activity levels of the enzyme
appeared to be seven years younger than their actual age, on average.
"Demonstrating arNOX as a source of certain visible signs of aging
validates our strategic focus of attacking the sources of aging," said Joe
Chang, Ph.D., chief scientific officer at Nu Skin. "Merely repairing damage to
the skin from environmental and mechanical stresses is no longer sufficient
for savvy consumers."
"The ground-breaking conclusions in this research, combined with trends of
an aging demographic, lead us to believe that there is sizable market
potential for a product that inhibits arNOX activity, and thus slows the
appearance of certain signs of aging," said Ashok Pahwa, chief marketing
officer at Nu Skin.
"Additionally, the lines between personal care and nutrition are
blurring," continued Pahwa. "Savvy consumers are increasingly aware of the
link between nutrition and beauty, and industry analysts report that products
to postpone aging will perhaps witness the strongest demand in upcoming
years."
Nu Skin currently holds patents and exclusive patent rights to arNOX
inhibitors and plans to commercialize the scientific advances under its new
product platform branded as ageLOC. The first topical ageLOC application will
be launched later this month. Because the arNOX enzyme is present throughout
the body, not just in the epidermis, the company is also conducting additional
studies to better understand the broader applications of ageLOC technology in
nutritional supplementation.
Authors of the study presented at IFSCC are Dale Kern, senior scientist at
Nu Skin, and Helen Knaggs, Ph.D., vice president of Nu Skin global research
and development; Wingfield Rehmus, M.D., clinical assistant professor in the
Department of Dermatology at Stanford School of Medicine; Dorothy Morre, PhD,
professor of foods and nutrition, Purdue University; and D. James Morre, PhD,
Dow distinguished professor of medicinal chemistry, Purdue University.
About arNOX
The arNOX enzyme is one in a class of newly-identified ECTO-NOX (external
NADH oxidase or ENOX) proteins that are located on external cell membranes.
ECTO-NOX proteins become increasingly active to generate additional metabolic
energy as cell mitochondria age and produce less energy. arNOX has been
identified in all cells tested, including serum and saliva and the dermis and
epidermis. Its unique property is that it generates superoxide at the cell
surface that is capable of damaging adjacent cells, lipoproteins, and other
structural components of the skin's extracellular matrix, such as collagen and
elastin. Other NOX categories include tumor-NOX, viral-NOX and constitutive,
or normal, NOX. Nu Skin has funded ENOX research by the Morres since 1999.
About IFSCC
The International Federation of the Societies of Cosmetic Chemists (IFSCC)
is a worldwide federation dedicated to international cooperation in cosmetic
science and technology. Today, 45 countries have met the high standards of
scientific and educational qualifications of the IFSCC and, as members,
support the organization's aims and programs. The number of individual members
in the Federation now exceeds 14,000. The IFSCC Congress is held every two
years and attracts 1,500 or more delegates. It is consistently one of the most
popular international meetings in the cosmetic industry.
The Company
Nu Skin Enterprises, Inc. is a global direct selling company operating in
more than 47 markets throughout Asia, the Americas and Europe. The company
markets premium-quality personal care products under the Nu Skin(R) brand,
science-based nutritional supplements under the Pharmanex(R) brand, and
technology-based products and services under the Big Planet(R) brand. Nu Skin
Enterprises is traded on the New York Stock Exchange under the symbol "NUS."
More information is available at http://www.nuskinenterprises.com.
SOURCE Nu Skin Enterprises Inc.

Jordan Karpowitz, +1-801-345-2187, jkarpowitz@nuskin.com, or Kara Schneck,
+1-801-345-2116, kschneck@nuskin.com, both of Nu Skin Enterprises Inc.