Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity...

Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological
Activity of Plain Resveratrol, Consistent With the Composition of
Longevinex(R)

SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program
drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine
molecule believed to largely be responsible for the French Paradox, the fact
the French have far more people living beyond 100 years and exhibit a far
lower mortality rate from heart disease than other people living in other
developed countries, despite the high-calorie, high-fat diet in France.

(Photo: http://www.newscom.com/cgi-bin/prnh/20080422/LATU004)

Now researchers in Sweden report that the full array of molecules provided in
red wine by far exceed the biological effects of plain resveratrol.

The results of the study are consistent with an earlier research study
conducted among mice which showed that the combination of resveratrol,
quercetin and rice bran phytate-IP6 (Longevinex(R)) exerted a 9-times greater
genomic effect than plain resveratrol or a calorie restricted diet.
[Experimental Gerontology 2008 Sep; 43(9):859-66]

Researchers instilled various white and resveratrol-rich red wines as well as
research-grade resveratrol into lab dishes with various types of cells (brain,
lung, colon, cervical, kidney). Surprisingly researchers found the total array
of molecules in red wine, but not white wine, produced a far greater
biological effect than resveratrol alone. Furthermore, the beneficial effects
were produced independently from alcohol or activation of the Sirtuin1 gene,
considered a survival and longevity gene.

Only at higher concentrations did resveratrol cause unhealthy cells to die off
(21%), compared to untreated cells (6%). Such a high concentration may produce
long-term side effects in humans. But within 24 hours, red wine abolished
virtually all (100%) the unhealthy cells. Red wine exerted its effect by
disarming protective antioxidant systems.

Researchers caution that this is only a lab dish study and that the results
are theoretical. But they seem to mirror the health-giving properties
attributed red wine as observed in human populations in France.

The researchers speculate that "instead of a single molecule (like
resveratrol) present in wine, ... the combination of molecules in red wine ...
contribute result in a combined effect with positive outcome."

Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), says
nutriceuticals have distinct advantages over drugs because they often provide
an array of molecules, whereas the FDA prefers to approve single-molecule
drugs.

"The synergism that nature produces, as seen in wine, may never be reproduced
in prescription drugs for this reason," says Sardi. "The development of a
plain resveratrol drug may not be as productive as first imagined," he says.

The patent-pending Longevinex(R) formula provides an array of molecules
including three found naturally in red wine - resveratrol, quercetin and
ferulic acid. The dosage of these molecules in Longevinex(R) is equivalent to
what is provided in 3-5 glasses of red wine (180-300 mg), considered the safe
and effective range observed in wine-drinking populations. [British Medical
Journal 1991 September 7; 303(6802): 565-568] Longevinex(R) is designed to
deliver the health benefits of red wine without the alcohol, calories or
sulfite preservatives.

The study was published in an early online edition (March 4, 2009) of
Experimental Cell Research.

For more information about Longevinex(R), please visit www.longevinex.com

Reference: Red wine triggers cell death and thioredoxin reductase inhibition:
effects beyond resveratrol and SIRT1. Experimental Cell Research 2009 Mar 4.
[Epub ahead of print]

SOURCE Longevinex

Bill Sardi of Longevinex, +1-909-596-9507, bsardi@aol.com