Research and Markets: Competitor Analysis: Hypoxia-Inducible Factor (HIF)

DUBLIN--(Business Wire)--
Research and Markets
(http://www.researchandmarkets.com/research/53daa0/competitor_analysi) has
announced the addition of the "Competitor Analysis: Hypoxia-Inducible Factor
(HIF)" report to their offering.

The present Competitive Intelligence Report about Hypoxia-Inducible Factor (HIF)
provides a competitor evaluation in the field of investigational small molecules
and RNA inhibiting HIF-1alpha or HIF-2 for treatment of cancer or acting as HIF
agonists to induce angiogenesis as of April 2009.

Hypoxia-inducible factor 1 (HIF-1) is a key regulator of angiogenic and glucose
metabolism processes utilised by tumour cells for survival and growth under
hypoxic conditions. While HIF-1a protein is found in a wide variety of human
primary tumors, it is only produced at very low levels in normal tissue. Because
of the important role that HIF-1a plays in regulating the response of growing
tumors to hypoxia, the protein is expected to have substantial value as a target
for therapeutic intervention. The protein is a key regulator of a large number
of genes important in cancer biology, including genes that regulate
angiogenesis, cell metabolism, cell proliferation, cell death (apoptosis) and
cell invasion. The first molecules inhibiting HIF-1alpha have entered clinical
development and others are to follow shortly including small molecules and RNA
interfering agents.

The report includes a compilation of current active projects in research and
development of HIF targeting small molecules, RNA or DNA. In addition, the
report lists company-specific R&D pipelines of HIF targeting molecules.

Competitor projects are listed in a tabular format providing information on:

* Drug Codes,
* Target / Mechanism of Action,
* Class of Compound,
* Company,
* Product Category,
* Indication,
* R&D Stage and
* additional comments with a hyperlink leading to the source of information.

Key Topics Covered:

* HIF-1alpha Inhibitors
* HIF-2 Inhibitors
* HIF Agonists
* Corporate HIF R&D Pipelines
* About La Merie

For more information visit
http://www.researchandmarkets.com/research/53daa0/competitor_analysi

Laura Wood
Senior Manager
press@researchandmarkets.com
Fax from USA: 646-607-1907
Fax from rest of the world: +353-1-481-1716

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