TRADE NEWS: Agilent Technologies Builds on 30-Percent LC/MS Growth With New Ultra-High-Def Q-TOF, Next-Gen ICP-MS, Higher Performance Triple Quad LC/MS

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Mon Jun 1, 2009 1:00pm EDT

Company Also Introduces Fast Track Application Kits, Metabolomics Portal and
Announces FAIMS, LDTD Collaborations 
PHILADELPHIA--(Business Wire)--
Two and a half weeks after Agilent Technologies Inc. (NYSE:A) announced its
liquid chromatography/mass spectrometry (LC/MS) sales were up 30 percent in the
second quarter of fiscal year 2009 compared with the previous year, the company
introduced:

* the first benchtop Ultra-High-Definition (UHD) Accurate Mass Quadrupole Time
of Flight (Q-TOF) LC/MS; 
* the next-generation Inductively Coupled Plasma Mass Spectrometer (ICP-MS); and

* a new Triple Quadrupole LC/MS delivering more sensitivity and speed than its
predecessor.

"We`ve been highly focused on building a large and loyal customer base in mass
spectrometry over the last five years, and it`s very gratifying to see this hard
work be so well-received," said Gustavo Salem, Agilent vice president and
general manager, Biological Systems Division. "Our plan is to continue
delivering the extra levels of performance, speed, robustness and ease-of-use
that are fueling Agilent`s strong growth in MS, while continuing to offer our
customers solutions with excellent value." 

The Highest-Performing Benchtop Q-TOF

The Agilent 6540 Ultra-High-Definition (UHD) Accurate Mass Q-TOF is by far the
highest performing benchtop Q-TOF on the market. It offers superior data quality
and advanced analytical capabilities, enabling researchers to profile, identify,
characterize and quantify low molecular-weight compounds and biomolecules with
greater confidence. It delivers far better performance than comparable Q-TOF
products without the inherent trade-offs in speed, resolution, dynamic range and
isotopic fidelity that are required by orbitrap-based systems. Innovative Ion
Beam Compression (IBC) and Enhanced Mirror Technology (EMT) produce
ultra-high-definition mass accuracy and mass resolution while maintaining a
benchtop format. 

"While others have pursued a `bigger must be better` approach to TOF flight tube
development, Agilent has used advanced engineering to dramatically improve
performance and maintain a benchtop-instrument format," said Ken Miller, Agilent
senior global marketing director for LC/MS. "We`ve achieved huge gains in mass
accuracy and resolution while maintaining our industry-leading sensitivity and
dynamic range. And the system can run fast to generate accurate mass MS and
MS/MS data for UHPLC analyses without the resolution loss suffered by orbitraps.
This is the perfect system for state-of-the-art qualitative analysis in support
of proteomic, metabolomic or non-targeted food safety and environmental
studies." 

Next-Gen ICP-MS Provides Unmatched Data Integrity

Agilent also chose ASMS 2009 to introduce the 7700 Series ICP-MS trace element
analyzer, the successor to the world`s best-selling ICP-MS, the Agilent 7500.
The 7700 Series provides unmatched data integrity, is simple to operate and
occupies the smallest footprint of any ICP-MS instrument. 

"ICP-MS analysis is becoming more routine while labs are measuring greater
numbers of elements, to lower levels, in more challenging samples. And there`s
growing demand for higher quality data along with more throughput and easier
operation," said Chris Toney, Agilent vice president and general manager, mass
spectrometry systems. "We set out to design a totally new instrument that
addresses these needs, and the early access users tell us that they`re very
pleased with the results." 

The most obvious feature of the new 7700 Series is its small size, occupying
just 73 cm of bench space. The mainframe footprint is more than 30 percent
smaller than any other ICP-MS. Despite its small footprint, the 7700 Series sets
a new standard for ICP-MS performance and ease-of-use in a rugged package. 

Collision/reaction cells have been adopted as the industry-standard technology
for removing spectral interferences in ICP-MS. Agilent`s Octopole Reaction
System (ORS), featuring helium collision mode, provides the most reliable and
effective interference removal, especially for complex and unknown sample types.
The 7700 Series features a new, third generation cell (ORS3) which further
improves the efficiency of helium mode, eliminating the need to use reaction
mode (with reactive cell gases such as hydrogen) in almost all applications.
This simplifies operation and eliminates false positives that frequently occur
with reaction mode, thereby improving data quality. 

The new collision/reaction cell, plus Agilent`s unique High Matrix Introduction
technology which is standard on the 7700, make the instrument particularly well
suited for complex sample types such as food, wastewater and soil digests, while
a redesigned ion lens improves sensitivity and reduces background noise across
the mass range. 

New Triple Quad Brings More Sensitivity, Faster Ion Monitoring, Faster Polarity
Switching

The new Agilent 6430 Triple Quadrupole LC/MS is the next generation of the
popular 6410 instrument, delivering higher sensitivity, faster monitoring of
ions and faster polarity switching. The Agilent 6430 is extremely well suited
for food testing, water analysis and protein biomarker discovery and validation,
and the huge added performance comes at a very modest price increase compared
with the previous model. 

"We`ve been very gratified with the strong acceptance of the 6400 family of
triple quads over the last three years, and this new model is a continuation of
our strategy to provide highly-sensitive, rugged, easy-to-use LC triple quads at
attractive prices," said Ken Miller, Agilent global marketing director, LC/MS. 

The 6430 shares many of the high-performance features of Agilent`s premium 6460
triple quadrupole MS, including an additional turbo pump for better ion
transmission and better sensitivity, an option for the 6410 which is now
standard on the 6430. The new instrument also features much faster polarity
switching, able to switch from positive ion mode to negative ion mode in 30 ms.
This allows greater flexibility to analyze complex mixtures, and to optimize
sensitivity by exploiting the most prolific ions for a given analyte. 

Kits to Fast Track New Pesticide and Toxicology Workflows

Agilent today also introduced pesticide and toxicology kits to help labs quickly
implement new workflows and generate high confidence results. 

"Instruments alone don`t solve business problems," said Denise Ibens, Agilent
solutions business development manager. "Agilent`s pesticides and toxicology
kits have been designed to specifically cut the costs of implementing new
technologies, increase confidence in initial results and reduce the time to
technical mastery." 

The new application kits include the latest techniques to improve productivity
in the laboratory such as GC Capillary Flow Technology, Deconvolution reporting
and large GCMS and LCMS screening databases to speed up data review and
analysis. 

The application kits include a method of analysis, the analytical column and a
documentation pack with a quick start guide. Some application kits even include
a free sample preparation pack, advanced video tools to learn additional system
features quickly and easily and application verification with a representative
checkout standard. The quick start kits are available for GC, LC, GC/MS and
LC/MS applications in food, environmental, forensics and petrochemical analysis.
Additionally, the Agilent GC and GCMS kits are preconfigured in manufacturing
and the applications are pretested to save days or even weeks of typical
start-up time and effort in the lab. 

Metabolomics Portal

Today Agilent also launched a Web portal focused on current trends and
accomplishments in metabolomics, regardless of instrumentation and software used
by the investigators. The URL is www.metabolomics-lab.com. 

Collaborations

Owlstone Nanotech Inc., a subsidiary of Advance Nanotech Inc. (OTCBB:AVNA), and
Agilent today announced a phase one agreement to develop Owlstone`s
field-asymmetric ion mobility spectrometry (FAIMS) filter as a front-end
separation module for Agilent Accurate Mass time-of-flight mass spectrometers
(TOF-MS). 

The goal is to determine how the systems can work together to enable
identification of previously unresolved analytes. The collaboration will also
explore how FAIMS can speed up liquid chromatographic separations, saving
valuable analysis time, and reduce ion suppression, improving method robustness
and sensitivity. 

Phytronix Technologies, Inc. and Agilent announced today that they have signed a
non-exclusive co-marketing agreement to promote the Phytronix Laser Diode
Thermal Desorption (LDTD) Ion Source with Agilent mass spectrometers. The LDTD
Ion Source, used with an Agilent mass spectrometer, offers ultra fast sample
analysis for both quantitative and qualitative applications in high-throughput
environments such as drug discovery processes (ADMET and DMPK), toxicology,
forensics, food safety, and environmental applications. 

The LDTD complements Agilent`s 1200 Series HPLC-Chip/MS. The latter provides
on-line LC/MS at nanoflow rates that are well-suited to applications where
sample amount is limited. The LDTD is based on a shotgun approach which uses the
separation power of the mass spectrometer for high throughput small molecule
quantitation in a myriad of applications. Agilent and Phytronix have
co-developed the interface between the LDTD and Agilent mass spectrometers to
provide life science users with throughput that can exceed 20,000 samples per
week. 

About Agilent Technologies

Agilent Technologies Inc. (NYSE:A) is the world`s premier measurement company
and a technology leader in communications, electronics, life sciences and
chemical analysis. The company`s 19,000 employees serve customers in more than
110 countries. Agilent had net revenues of $5.8 billion in fiscal 2008.
Information about Agilent is available on the Web at www.agilent.com. 

NOTE TO EDITORS: Further technology, corporate citizenship and executive news is
available on the Agilent news site at www.agilent.com/go/news. 

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Agilent Technologies Inc.
Stuart Matlow, +1-408-553-7191
stuart_matlow@agilent.com



Copyright Business Wire 2009

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