Research and Markets: Epigenetic Targets in Drug Discovery - Everything a Drug Researcher Needs to Know about Targeting Epigenetic Mechanisms of Disease

DUBLIN--(Business Wire)--
Research and Markets
(http://www.researchandmarkets.com/research/475fd2/epigenetic_targets) has
announced the addition of John Wiley and Sons Ltd's new report "Epigenetic
Targets in Drug Discovery" to their offering.

Fueled by the expertise of a team of international specialist authors, this
first reference on the booming topic covers everything a drug researcher needs
to know about targeting epigenetic mechanisms of disease.

The first part of the book surveys current methodologies for finding and
validating drug candidates that act via epigenetic mechanisms. The second part
systematically surveys known and suspected drug targets within the epigenetic
machinery, including the discovery and development of vorinostat, the first
marketed epigenetic drug.

Key Topics Covered:

PART I: General aspects and methodologies.

1 New Frontiers in Epigenetic Modifications.

2 Structural Biology of Epigenetic Targets.

3 Computer- and Structure-based Lead Identification for Epigenetic Targets.

4 Histone Modification Analysis Using Mass Spectrometry.

5 In-vitro Assays for Histone Modifying Enzymes.

6 Epigenetic Targets in Drug Discovery: Cell-based assays for HDAC inhibitor hit
validation.

7 Chromatin Immuno Precipitation ChIP: wet lab meets in silico.

PART II: Epigenetic Target Classes and Inhibitor Development.

8 DNA Methyltransferase Inhibitors.

9 Histone Deacetylase Inhibitors.

10 NAD-Dependent Deacetylases as Therapeutic Targets.

11 Inhibitors of Histone Acetyltransferases: Discovery and Biomedical
Perspectives.

12 Histone Methyltransferases as Novel Drug Targets.

13 Histone Demethylases.

For more information visit
http://www.researchandmarkets.com/research/475fd2/epigenetic_targets

Laura Wood
Senior Manager
press@researchandmarkets.com
Fax from USA: 646-607-1907
Fax from rest of the world: +353-1-481-1716

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