Blind Patient Regains Sight with "Eyetooth" Implanted in Her Eye

Wed Sep 16, 2009 4:09pm EDT

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Bascom Palmer Eye Institute Performs First MOOKP Procedure in USA
MIAMI--(Business Wire)--
Blind for nine years, Sharron "Kay" Thornton has just regained her sight through
a first-in-the-U.S. surgical procedure at Bascom Palmer Eye Institute at the
University of Miami Miller School of Medicine. The procedure -- modified
osteo-odonto-keratoprosthesis (MOOKP) -- implanted her eyetooth in her eye, as a
base to hold a prosthetic lens. 

"I`m looking forward to seeing my seven youngest grandchildren for the first
time," said Thornton, 60, of Smithdale, Miss., who was blinded by
Stevens-Johnson syndrome in 2000. The rare, serious skin condition destroys the
cells on the surface of the eye causing severe scarring of the cornea. "We take
sight for granted, not realizing that it can be lost at any moment," she said.
"This truly is a miracle." 

On Labor Day weekend, after the last in a series of surgeries by corneal
specialist Victor L. Perez, M.D., associate professor of ophthalmology at Bascom
Palmer Eye Institute, bandages were removed from Thornton`s eyes and she was
able to recognize faces only hours after her surgery. Two weeks following her
surgery, she is already reading newsprint with a visual acuity of 20/70 and it
is expected to improve further as her surgical scars heal. 

"Through the work of Dr. Perez`s team, patients in the United States now have
access to this complex surgical technique, which has been available only in a
limited number of centers in Europe and Asia," said Dr. Eduardo C. Alfonso,
M.D., chairman of Bascom Palmer Eye Institute (www.bascompalmer.com), the
nation`s #1-ranked eye hospital. 

Developed in Italy, MOOKP has proven effective as a solution to end-stage
corneal disease where severe corneal scarring blocks vision and corneal
transplants are no longer an option but the eye`s internal structures and optic
nerve remain healthy. Patients may have suffered trauma to their cornea, the
outside surface of the eye where a contact lens would sit, from chemical
injuries, thermal burns, and inflammatory or autoimmune disorders, such as
Stevens-Johnson syndrome. 

"For certain patients whose bodies reject a transplanted or artificial cornea,
this procedure `of last resort` implants the patient`s tooth in the eye to
anchor a prosthetic lens and restore vision," explained Dr. Perez. "In Sharron`s
case, we implanted her canine tooth, her eyetooth." 

Dr. Perez`s interdisciplinary team included Yoh Sawatari, D.D.S., assistant
professor of clinical surgery at the Division of Oral and Maxillofacial Surgery
and Dentistry at the University of Miami/Jackson Memorial Medical Center, who
extracted the patient`s canine or "eyetooth" and surrounding bone. In MOOKP, the
tooth and surrounding bone are shaved and sculpted, and a hole is drilled for
the insertion of an optical cylinder lens. Next, to bond the tooth and lens as a
bio-integrated unit, they are implanted under the patient`s skin in the cheek or
shoulder. Meanwhile, the ophthalmologist prepares the surface of the eye for
implantation of the prosthesis by removing scar tissue surrounding the damaged
cornea. 

About one month later, mucous material is collected from the inside of the
patient`s cheek and used to cover and rehabilitate the surface of the damaged
eye. In the final phase, usually two months later, the prosthesis is removed
from the cheek or shoulder and implanted in the eye. The prosthesis is carefully
aligned with the center of the eye, and a hole is made in the mucosa for the
prosthetic lens, which protrudes slightly from the eye and enables light to
re-enter the eye allowing the patient to see once again. 

For Thornton, the surgery marked the successful conclusion of a nine-year
medical odyssey that started at the onset of Stevens-Johnson syndrome. 

Six years ago, a friend drove Thornton 900 miles to Bascom Palmer for an
ophthalmic evaluation. A stem cell procedure was performed, but proved
unsuccessful. Since she was not a candidate for a cornea transplant, she was
referred to Dr. Perez, another Bascom Palmer surgeon who was exploring the
possibility of the MOOKP technique. "I`m so thankful that the doctors at Bascom
Palmer never gave up on me - they kept searching," said Thornton. Last year, Dr.
Perez traveled to Europe for training by Italian ophthalmologist Giancarlo
Falcinelli, M.D., who developed the MOOKP procedure, building on the original
OOKP technique developed in the 1960s by Professor Benedetto Strampelli, M.D.,
also of Italy. 

Now Thornton is excited about seeing her three grown children and nine
grandchildren - as well as rediscovering simple joys like watching clouds and
playing cards again with friends. "Without sight, life is really hard. I`m
hoping this surgery will help countless people," she said. 

Editorial Note: Photos, illustrations, videos, animations and interview with
physicians and patient are available upon request. 

About Bascom Palmer Eye Institute

Bascom Palmer Eye Institute has earned an international reputation as one of the
premier providers of eye care in the world and is the largest ophthalmic care,
research and educational facility in the southeastern United States. More than
250,000 patients are treated each year with nearly every ophthalmic condition
and more than 18,000 surgeries are performed annually. With patient care
facilities in Miami, Palm Beach Gardens, Naples and Plantation, the institute
serves as the Department of Ophthalmology for the University of Miami Miller
School of Medicine. 

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Bascom Palmer Eye Institute
Marla Bercuson, 305-326-6190
mbercuson@med.miami.edu
or
Cynthia Birch, 305-326-6078
cbirch@med.miami.edu



Copyright Business Wire 2009

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