Experts Summarize State of the Science in Autism Disorders

Research Progresses on Many Fronts, But Much Work Remains

PHILADELPHIA, Oct. 14 /PRNewswire-USNewswire/ -- Scientific understanding and
medical treatments for autism spectrum disorders (ASDs) have advanced
significantly over the past several years, but much remains to be done, say
experts from the Center for Autism Research at The Children's Hospital of
Philadelphia who published a scientific review of the field today.

"We summarized many new findings by autism researchers throughout the world,
and give our perspective on the current state of the science in autism
spectrum disorders," said lead author Susan E. Levy, M.D., a developmental
pediatrician and medical director of the Regional Autism Center at Children's
Hospital. "We hope our review will be a useful reference for healthcare
professionals working with ASD patients and families."

The article appears in the British journal The Lancet, published online on
Oct. 12. Levy co-authored the review with Robert T. Schultz, Ph.D., a
neuropsychologist and director of the Center for Autism Research at Children's
Hospital, and David S. Mandell, Sc.D., a psychiatric epidemiologist at the
University of Pennsylvania School of Medicine.

Some recurrent themes of the review are the expanding knowledge of early brain
development, and the importance of early diagnosis of ASDs, accompanied by
intensive early treatment. The researchers also recognize the important role
of parent involvement in early recognition of ASDs and in reinforcing their
child's behavioral treatments at home. They also endorse research on methods
for supporting families to reduce parental stress.

As evidenced by a long history of family and twin studies, ASDs are the
neuropsychiatric disorder most affected by genetic factors. The authors review
recent studies performed with the help of sophisticated gene-analyzing tools,
and cite the finding earlier this year that a significant percentage of ASD
patients have DNA alterations in a genetic area that affects how neurons
interconnect in the brain. Combined with other studies of brain anatomy and
function, the authors say, "genetic and neurobiological evidence point to a
good causal model of this disorder--namely, genetically mediated abnormal
findings of synaptic maturation and connectivity."

Further research is needed to explain in detail how genes affect the
development of brain cell interconnections, but the authors say that future
investigation may suggest techniques to intervene early in life with medical
treatments.

Neuroimaging tools, such as magnetoencephalography (MEG), a method of mapping
the brain's magnetic field, hold the potential of identifying a biological
signature of ASDs, so that clinicians might identify autism during early
childhood and monitor the effectiveness of treatments.

Regarding therapy, the authors note that the most researched treatments are
those based on applied behavioral analysis, which includes intensive, highly
structured treatments beginning in early childhood. More recently, those
highly structured programs have been combined with other behavioral programs
more akin to real-life situations, with increased effectiveness.

Although existing drugs do not treat core symptoms of ASDs, the authors refer
to results showing medications may be effective in relieving related symptoms
such as irritability and anxiety. Many other proposed and existing treatments,
both biological and non-biological, have not been adequately studied.

In sum, say the authors, "no cure for autism spectrum disorders is yet
available." However, "outcomes are improved with early detection and intensive
treatment." In the future, the authors conclude that advances in early
detection and diagnosis will allow more individualized and effective early
treatment to alter the course of early behavior and brain development.

The authors received grant support from the CDC, the National Institutes of
Health, the National Science Foundation, the Pennsylvania Department of
Health, the U.S. Department of Defense and the U.S. Department of Education.

Levy SE, Mandell DS, Schultz RT. Autism. Lancet. Published online Oct. 12,
2009. DOI:10.1016/S0140-6736(09)61376-3.

About Autism Programs at The Children's Hospital of Philadelphia: The Center
for Autism Research (CAR) is a collaborative effort between Children's
Hospital and the University of Pennsylvania. CAR's goals are to identify the
causes of autism spectrum disorders (ASDs) and develop effective treatments.
Since CAR's establishment in 2008, CAR researchers have collectively published
over 50 papers on many aspects of ASDs. The Regional Autism Center (RAC) is a
multidisciplinary center for assessment, management and research related to
children and adolescents with ASDs. The core team includes
developmental-behavioral pediatricians, psychologists, nurse practitioners,
speech/language pathologists, occupational therapists and social workers.
Patients are seen for diagnostic evaluation and second opinion regarding
diagnosis, recommendations for services and treatments, and consultation for
treatment program design.

About The Children's Hospital of Philadelphia: The Children's Hospital of
Philadelphia was founded in 1855 as the nation's first pediatric hospital.
Through its long-standing commitment to providing exceptional patient care,
training new generations of pediatric healthcare professionals and pioneering
major research initiatives, Children's Hospital has fostered many discoveries
that have benefited children worldwide. Its pediatric research program is
among the largest in the country, ranking second in National Institutes of
Health funding. In addition, its unique family-centered care and public
service programs have brought the 430-bed hospital recognition as a leading
advocate for children and adolescents. For more information, visit
http://www.chop.edu.

Contact: John Ascenzi
The Children's Hospital of Philadelphia
Phone: (267) 426-6055
Ascenzi@email.chop.edu

SOURCE The Children's Hospital of Philadelphia

John Ascenzi of The Children's Hospital of Philadelphia, +1-267-426-6055,
Ascenzi@email.chop.edu