OSI Pharmaceuticals to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on Tuesday, November 17, 2009

MELVILLE, N.Y.--(Business Wire)--
OSI Pharmaceuticals, Inc. (NASDAQ: OSIP) announced today that OSI Management
will present at the Lazard Healthcare Conference in New York, NY on Tuesday,
November 17, 2009 at 8:55am (Eastern Time) and will provide an overview on the
Company`s product portfolio and business developments.

The presentation will be webcast live and may be accessed by visiting OSI`s
website at www.osip.com. A replay of the webcast will also be available on the
Company`s website until December 1, 2009.

About OSI Pharmaceuticals

OSI Pharmaceuticals is committed to "shaping medicine and changing lives" by
discovering, developing and commercializing high-quality, novel and
differentiated targeted medicines designed to extend life and improve the
quality of life for patients with cancer and diabetes/obesity. For additional
information about OSI, please visit http://www.osip.com.

This news release contains forward-looking statements. These statements are
subject to known and unknown risks and uncertainties that may cause actual
future experience and results to differ materially from the statements
made.Factors that might cause such a difference include, among others, OSI's and
its collaborators' abilities to effectively market and sell Tarceva and to
expand the approved indications for Tarceva, OSI`s ability to protect its
intellectual property rights, safety concerns regarding Tarceva,competition to
Tarceva and OSI`s drug candidatesfrom other biotechnology andpharmaceutical
companies, the completion of clinical trials, the effects of FDA and other
governmental regulation, including pricing controls,OSI's ability to
successfully develop and commercialize drug candidates, and other factors
described in OSI Pharmaceuticals' filings with the Securities and Exchange
Commission.

OSI Pharmaceuticals, Inc.
Kathy Galante (investors/media)
SeniorDirector
Kim Wittig (media)
Director
631-962-2000
or
Burns McClellan, Inc. (representing OSI)
Justin Jackson/Kathy Nugent (media)
212-213-0006

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