Factbox: The drugs that caused Michael Jackson's death

Mon Feb 8, 2010 8:14pm EST

(Reuters) - Michael Jackson's personal doctor was charged on Monday with involuntary manslaughter in the singer's death in June. Dr. Conrad Murray was caring for Jackson at the rented Los Angeles home where he died on June 25 at age 50.

The Los Angeles coroner said in August that Jackson's death was caused mainly by two sedatives -- propofol and lorazepam. Other prescription medications were also found in his system. A full autopsy report released on Monday lists "acute propofol intoxication" as the principal cause of death.

Here are some facts about the drugs found in Jackson's body according to the coroner's report:

* Propofol, also known by the trade name Diprivan, is used to sedate patients on breathing machines or before procedures such as colonoscopies. Given properly, it does not render patients unconscious, but they usually cannot remember the procedure.

The autopsy report said the amount of propofol found in Jackson's system was equivalent to that used during anesthesia for major surgery. It added that there were "no reports of its use in insomnia relief."

* The American Society of Anesthesiologists says propofol should "never be used outside of a controlled and monitored medical setting." The autopsy report said there was no resuscitation or monitoring equipment found in Jackson's room.

* Lorazepam, sold under the brand names Ativan and Temesta, is one of a class of drugs known as benzodiazepines, which include Valium. They are often used to allay anxiety when given as pills and can be administered intravenously before surgery to relax patients.

* Diazepam, the generic version of Valium, was also found in Jackson's blood.

* Midazolam is a sedative similar to propofol that is used to make patients drowsy, but not unconscious, during procedures.

* Lidocaine, also known as Xylocaine, is a painkiller that can be injected to numb an area before surgery.

* Ephedrine is a stimulant and decongestant, similar to the ingredients in the over-the-counter pill Sudafed and also to the illegal "upper" methamphetamine. Many states now control over-the-counter distribution of drugs like Sudafed that contain pseudoephedrine because it can be used to make illegal drugs.

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