Scientists find "mother" of all skin cells

LONDON Thu Mar 11, 2010 2:31pm EST

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LONDON (Reuters) - Scientists have found the "mother," or origin, of all skin cells and say their discovery could dramatically improve skin treatments for victims of serious wounds and burns.

Hans Clevers and a team of Dutch and Swedish researchers conducted a study in mice and found that the stem cell that gives produces all the different cells of the skin actually lives in hair follicles.

The findings, which they say will translate for human use, mean it may be possible to harness these stem cells to help with wound repair or skin transplants for burns victims, they said in a study in the Science journal on Thursday.

"This is the mother of all the stem cells in the skin -- it makes all the other stem cells," Clevers, of the Royal Netherlands Academy of Arts and Sciences in Utrecht, told Reuters in a telephone interview.

"The same stem cells exist in humans, we can see them, and the promise is that these cells are probably going to be much better than anything we have had to date at making new skin."

The skin has three different populations of cells -- hair follicles, moisturizing sebaceous glands, and the tissue in between, known as the interfollicular epidermis. Stem cells are original cells, or drivers, from which all human cells develop.

Scientists had previously thought that stem cells in each of these three skin populations were capable of producing their own cell type, but until now, a "mother" stem cell which produces all three types had not been found.

Clevers' team found that a group of stem cells that live in hair follicles and which have high levels of a gene called Lgr6 are the original epidermal stem cells.

In tests on mice with wounds, they found that Lrg6 cells around the wound drove new skin growth and repaired the skin.

Scientists are already able to grow new skin in laboratories using tissue from existing skin cells from patients who have been badly burned, but the new skin is often brittle, dry and does not have hair -- making it look unusual.

Clevers said the advantage offered by the "mother" stem cell finding would be that they could grow skin from its original basis -- allowing it to be "real new skin" with moisture from sebaceous glands and the ability to grow hair.

He said researchers now need to learn how to isolate the Lrg6 cells from human skin. That could take 2 to 3 years.

"We are learning how to grow the mouse cells in culture. Once we know how to do this and can isolate the human variant, we should be able to grow human cells as well," he said.

"Since there is a lot of experience already with growing and transplanting skin for burn wound patients, it should be relatively easy to incorporate the new stem cells ... and conduct trials in patients."

(Editing by Elizabeth Fullerton)

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