Antidepressants can help people with physical ills

Tue Mar 16, 2010 8:01pm EDT

* Review of 51 studies shows antidepressants can help

* Findings already being used to update treatment guidelines

LONDON, March 17 (Reuters) - Antidepressants such as Eli Lilly's (LLY.N) Prozac or GlaxoSmithKline's (GSK.L) Paxil can help depressed patients with physical illness, and doctors should consider them more often, researchers said on Wednesday.

While around 10 percent of patients with physical diseases are thought to suffer from depression, studies suggest doctors are less likely to prescribe antidepressants because they are not sure if the medicines will work well.

A systematic review by British scientists found the drugs were more effective than placebos, or dummy pills, at treating depression in patients with physical illnesses including stroke, HIV/AIDS, Parkinson's disease and various types of cancer.

The findings are already being used to update European guidelines on treating depression, experts said.

"I see many patients struggling with the effects of physical disease on their mental health," said Matthew Hotopf of King's College London's Institute of Psychiatry, who led the study.

"This is a critical area of research which will help doctors maximise a patient's treatment and recovery from the mental and physical symptoms of illness."

The research, a Cochrane Library review which analysed 51 studies on antidepressants versus placebos, found that for every six people being treated, one more was likely to benefit at 6-8 weeks if they were taking antidepressants.

Most of the studies looked at selective serotonin reuptake inhibitors (SSRIs), like Prozac, or at an older class of drugs called tricyclic antidepressants, like Norpramin, made by Sanofi-Aventis (SASY.PA). Around 3,600 patients were involved.

"This research is very important for millions of patients and families who are experiencing physical illness," said Irene Higginson of the Cicely Saunders Institute at King's College London, who also worked on the study.

"Until now many doctors and nurses were worried that these treatments did not work well in people with physical illness. This result shows that they are usually of benefit. Already we are using the results to inform a new European guideline for doctors and nurses on the management of depression." (Editing by Dan Lalor)

Related Quotes and News

Company
Price
Related News
We welcome comments that advance the story through relevant opinion, anecdotes, links and data. If you see a comment that you believe is irrelevant or inappropriate, you can flag it to our editors by using the report abuse links. Views expressed in the comments do not represent those of Reuters. For more information on our comment policy, see http://blogs.reuters.com/fulldisclosure/2010/09/27/toward-a-more-thoughtful-conversation-on-stories/
Comments (2)
bruby1975 wrote:
yes those anti-depressants can really help the patients-the patients get better physically until they kill others and themselves due to high incidence of “suicidal ideation” as a major, often not mentioned side effect. Just treat the patients with excellent physical medicine and don’t use this junk!

Mar 17, 2010 11:13am EDT  --  Report as abuse
Laurie104 wrote:
So 1 in 6 does well at 6-8 weeks use and this is reported as a positive effect? At 6-8 weeks use the adverse reactions/side effects to ssri’s haven’t even surfaced yet. I could show 1 in 6 positive results with an asprin!
Do a study on those on ssri’s for years and then report back.

The next obvious question is who funded this study?

Mar 17, 2010 2:06pm EDT  --  Report as abuse
This discussion is now closed. We welcome comments on our articles for a limited period after their publication.