UPDATE 1-Dynavax hep B vaccine shows promise in kidney disease

Wed Apr 14, 2010 5:17pm EDT

* Heplisav protects kidney disease patients in Ph II study

* Shares up 35 pct in after-hours trade

April 14 (Reuters) - Dynavax Technologies Corp (DVAX.O) said a mid-stage study of its experimental hepatitis B vaccine showed that it protected patients with chronic kidney disease from the virus, when measured at week 24.

The vaccine, Heplisav, protected all dialysis and pre-dialysis patients with chronic kidney disease, the company said in a statement.

The study compared two Heplisav regimens -- a single-dose vaccine and a double-dose vaccine -- and enrolled 41 subjects between 40 and 70 years with progressive loss of renal function.

Chronic kidney disease patients undergoing dialysis are at high risk of hepatitis B infection, the company said.

In March 2008, U.S. Food and Drug Administration had put a clinical hold on the vaccine. It is currently in late-stage trials, after the FDA removed the hold last September.

Shares of the company were up 35 percent to $1.95 in trading after the bell. They closed at $1.45 Wednesday on Nasdaq. (Reporting by Esha Dey in Bangalore; Editing by Unnikrishnan Nair)

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