Multivitamins no fountain of youth for women

NEW YORK Mon Oct 10, 2011 5:23pm EDT

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NEW YORK (Reuters Health) - Women taking multivitamins don't live longer than those who get their nutrients from food alone, a new U.S. study shows.

In fact, they appear to have slightly higher death rates, researchers found.

"There is very little evidence showing that common dietary supplements would be beneficial in prevention of major chronic diseases," said Dr. Jaakko Mursu of the University of Minnesota in Minneapolis, who worked on the new study.

"Unless you are deficient, there is hardly any reason to take them," he told Reuters Health.

About half of adult Americans take dietary supplements, and the industry now boasts of annual sales as high as $20 billion.

Yet research suggests that some of the largely unregulated substances -- such as vitamins A and E -- could be harmful in high doses, according to an editorial published along with the new findings in the Archives of Internal Medicine.

"The belief that antioxidant supplements are beneficial seems likely to have resulted from a collective error," Dr. Goran Bjelakovic of the University of Nis in Serbia and Dr. Christian Gluud of Rigshospitalet in Copenhagen write. "Perhaps oxidative stress is one of the keys to extension of our life span."

Mursu and his colleagues used data from nearly 39,000 older women who participated in the Iowa Women's Health Study and filled out questionnaires starting in 1986.

The survey asked about use of multivitamins, vitamins A, C, D and E as well as beta-carotene, B vitamins and minerals such as calcium, copper, magnesium, selenium and zinc.

During the study, supplements became increasingly popular: Between 1986 and 2004, the proportion of women who said they took one or more jumped from 63 percent to 85 percent.

Only calcium supplements were linked to a lower risk of death over 19 years of follow-up, with 37 percent of users dying compared to 43 percent of nonusers. That link held up even after considering that women taking supplements had a healthier lifestyle than the rest.

By contrast, women taking other supplements did not live longer. For instance, 41 percent of multivitamin users died versus 40 percent of nonusers -- and the gap became even wider when adjusting the numbers based on health problems like diabetes, high blood pressure and overweight in the two groups.

Mursu said he expects his findings will be true for men as well, adding that they jibe with earlier research hinting that dietary supplements do little good in Western countries where vitamin deficiency is not common.

One possible exception is vitamin D, which one recent study suggests may help women live a little longer.

Mursu also cautioned that his study doesn't prove supplements cause harm.

"I would rather conclude that there is no evidence for benefits," he said.

The 2010 U.S. dietary guidelines recommend getting nutrients from foods, not supplements.

However, women of reproductive age group are advised to get extra folic acid and those who are pregnant may want to take iron supplements if their doctor suggests it. The guidelines also urge people 50 and older to get extra vitamin B12 from fortified foods or supplements.

The government website has tips on how to eat a balanced diet. Information on individual supplements can be found at


Duffy MacKay of the Council for Responsible Nutrition, a trade association representing manufacturers and ingredient suppliers of dietary supplements, disagreed with the researchers' conclusion that doctors should only recommend supplements to people with deficiencies.

He added that in the case of iron, women on high doses may have underlying conditions that could explain their higher death rates.

While Mursu acknowledged that shortcoming, he said it is unlikely to be relevant for multivitamins, which usually aren't prescribed by a doctor.

Short of getting sick, he said it's hard to know if you are getting enough vitamins and minerals -- and screening everybody would be prohibitively expensive.

His advice?

"Include as many vegetables and as much fruit as you can. There is hardly any reason to limit those, and they contain a whole lot of vitamins and minerals."

SOURCE: Archives of Internal Medicine, October 10, 2011.

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Comments (2)
Yes, just keep getting cancer and lots of other ailments. Doctors will keep taking your money. The relentless attack on nutrition has continued for over 50 years. Which drug company paid for this study?

Oct 10, 2011 5:41pm EDT  --  Report as abuse
mindopen wrote:
According to what I have read it’s the Iowa Women’s Health Study. The one that conducted to so called study on womens’ hormone therapy a couple of years ago that stirred up a huge controversy that was found to be inaccurate and sent women into a spiral of doubt over their hormone therapy. The article in also stated that their study showed that the women in the study were more likely to use estrogen replacement therapy! I guess the IWHS should know about that! I agree, follow the money. This is the drug companies attempts (again) to take vitamins off the market and into their control. I would like to know what data was collected since 2004 when the so called self-reported data stopped. What happened to the last 7 years? Some PHD at the University of Eastern (as opposed to Western Finland?) Finland says in a article that “little is known about the long-term effects of multivitamin use and less commonly used supplements, such as iron and other minerals.” Funny, I have been taking “ONE A DAY” for about 50 years now! Short of some colds and sinus problems, I’ve been pretty healthy for 58 years. Funny that my husband was put on a regular multivitamin WITHOUT iron years ago because his iron levels were too high, and this would have put him at risk of a coronary, sounds like someone knew about that! We better watch to see where this is heading.

Oct 13, 2011 6:59am EDT  --  Report as abuse
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