ABLYNX AND ALGETA ENTER INTO A RESEARCH COLLABORATION TO EVALUATE THE POTENTIAL OF NOVEL ALPHA-PHARMACEUTICALS COMPRISING THORIUM-277 CONJUGATED TO TUMOUR-TARGETING NANOBODIES
GHENT, Belgium and OSLO, Norway, 21 November 2012 - Ablynx [Euronext Brussels: ABLX] and Algeta ASA [OSE: ALGETA] announce a research collaboration to evaluate a novel Targeted Thorium Conjugate (TTC) based on combining Algeta's proprietary thorium-227 alpha-pharmaceutical payload with Nanobodies® generated using Ablynx's proprietary technology platform.
Under the terms of the collaboration, Ablynx will provide access to novel Nanobodies against a specific, undisclosed target and Algeta will provide access to chelation and conjugation technologies, as well as to its alpha-emitter thorium-227. Both companies will contribute resources towards the collaboration, which is expected to last for up to a year initially with the option for extension thereafter. No further terms have been disclosed.
Andreas Menrad, Chief Scientific Officer of Ablynx, said:
"We are very pleased to be working with Algeta to discover and develop novel cancer therapeutics based on both companies' proprietary technologies. Our Nanobodies have the potential to selectively and efficiently deliver Algeta's thorium-227 to the site of the tumour. We are very excited about combining our unique and powerful technology with Algeta's leading payload expertise to search for breakthrough opportunities in oncology."
Thomas Ramdahl, Executive Vice President and Chief Technology Officer of Algeta, said:
"The collaboration with Ablynx, the fifth TTC programme to be disclosed by Algeta, is designed to evaluate the potential of a Nanobody to act as the targeting molecule for the alpha-pharmaceutical payload, thorium-227. This payload has the potential to provide higher potency and more effective delivery over other therapeutic payloads, with the further advantage that there are no known cellular resistance mechanisms to the cell killing properties of alpha particles."
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Ablynx is a biopharmaceutical company engaged in the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious human diseases, including inflammation, haematology, oncology and pulmonary disease. Today, the Company has approximately 25 programmes in the pipeline and seven Nanobodies at clinical development stage. Ablynx has ongoing research collaborations and significant partnerships with major pharmaceutical companies including Boehringer Ingelheim, Merck KGaA, Novartis and Merck & Co. The Company is headquartered in Ghent, Belgium. More information can be found on www.ablynx.com.
About the Ablynx Nanobody platform
Nanobodies are antibody-derived therapeutic proteins that contain the unique structural and functional properties of naturally-occurring heavy-chain antibodies. The Nanobody technology was originally developed following the discovery that camelidae (camels and llamas) possess fully functional antibodies that lack light chains. These heavy-chain antibodies contain a single variable domain (VHH) and two constant domains (CH2 and CH3). Importantly, the cloned and isolated VHH domain is a perfectly stable polypeptide harbouring the full antigen-binding capacity of the original heavy-chain antibody. These newly discovered VHH domains with their unique structural and functional properties form the basis of a new generation of therapeutic antibodies which Ablynx has named Nanobodies.
Algeta is a company focused on developing novel targeted therapies for patients with cancer based on its alpha-pharmaceutical platform. The Company is headquartered in Oslo, Norway, and has a US subsidiary, Algeta US, LLC, based in Cambridge, MA performing commercial marketing operations in the US. Algeta is listed on the Oslo Stock Exchange (Ticker: ALGETA). For more information please visit www.algeta.com.
About the Algeta TTC Platform
 Hall (1994) Radiobiology for the Radiologist (Lippincott, Philadelphia)
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Source: Ablynx via Thomson Reuters ONE
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