UPDATE 2-Sanofi boosting stake in U.S. biotech Regeneron
* Sanofi to buy Regeneron shares on open market
* Regeneron shares rise 2.8 percent
* Sanofi up 3.4 percent (Adds analyst and company comments, background on partnership, byline)
By By Ransdell Pierson
Feb 11 (Reuters) - French drugmaker Sanofi SA is buying more shares in U.S. biotech company Regeneron Pharmaceuticals Inc, its partner in the development of potential blockbuster treatments for cholesterol and rheumatoid arthritis.
Sanofi's plans, disclosed by the companies in separate statements on Monday, boosted both companies' shares.
Sanofi controls 16.7 percent of Regeneron, or 15.82 million shares, according to Reuters data. Sanofi said in an email that it has the right to raise the stake to as much as 30 percent under its decade-long partnership with Regeneron.
"We are very happy with the relationship with Regeneron, but we needed this technical filing to get freedom to operate," the company said. Sanofi disclosed its plans to buy Regeron shares on the open market in a filing with the U.S. Federal Trade Commission.
Peter Dworkin, a spokesman for Regeneron, said that under terms of their partnership, Sanofi is not allowed to increase its stake beyond 30 percent until five years after the planned 2017 conclusion of their collaboration.
"The 30 percent limit they can acquire without our permission is in force and will remain in force" until 2022, Dworkin said.
Under the partnership, Sanofi and Regeneron have agreed to equally split U.S. profits from medicines they develop together.
Regeneron Chief Executive Leonard Schleifer has said his company enjoys "unprecedented" favorable financial terms from the partnership because Sanofi funds 100 percent of expenses to develop their drugs.
"I think this is a sign that they (Sanofi) are taking more interest in the company," said Deutsche Bank analyst Robyn Karnauskas. "I don't think investors should immediately conclude that an acquisition is coming soon."
Morningstar analyst Lauren Migliore said it was unclear whether Sanofi was merely boosting its stake in Regeneron or eventually aimed for a controlling stake or outright ownership.
"I wouldn't want to speculate either way," Migliore said. "But Regeneron has a great drug portfolio and technology and a very strong partnership with Sanofi, so a merger would make sense."
She also said a merger would be costly because acquirers typically have to pay premiums of 30 to 100 percent for shares of attractive biotechs, and Regeneron's stock has risen more than fourfold in the past two years. The company's valuation has soared on booming sales of Eylea, a treatment for macular degeneration, and greater awareness on Wall Street of its promising experimental drugs.
Regeneron shares were up 2.8 percent in afternoon trading. Shares of Sanofi, whose earnings have been hurt by generic competition for its Plavix blood-clot preventer, rose 3.4 percent in Paris.
Regeneron is best known for Eylea, co-marketed with Bayer AG . The drug is expected to garner sales this year of up to $1.3 billion.
U.S. regulators last summer approved Regeneron's Zaltrap treatment for metastatic colorectal cancer, co-developed with Sanofi. Analysts believe the drug could eventually bring in annual sales of $400 million.
Investors are closely watching the Regeneron-Sanofi cholesterol drug, which is in late-stage trials. The drug has slashed levels of "bad" LDL cholesterol by 60 percent through a new mechanism - blocking a protein called PCSK9.
Another drug from the partnership, which blocks an inflammation-causing protein called interleukin 6, is being tested against rheumatoid arthritis. Some analysts believe the cholesterol and arthritis drugs could each become $1 billion-a-year sellers if approved.
The expiration of Sanofi's patent on Plavix, once the world's second-best-selling prescription drug, is expected to slice around $1.1 billion off earnings in the first half of 2013, Sanofi said last week. The company aims to have 18 new drugs on the market by 2015.
(Additional reporting by Debra Sherman in Chicago, Elena Berton in Paris and Zeba Siddiqui in Bangalore; Editing by John Wallace)
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