TRADE NEWS: Agilent Technologies Introduces HaloPlex Exome Kits and SureCall Software

Thu Feb 21, 2013 11:00am EST

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New Offerings Extend Target-Enrichment Workflow, from Custom Assay Design to
Mutation Report
SANTA CLARA, Calif.--(Business Wire)--
Agilent Technologies Inc. (NYSE: A) today expanded its portfolio of
target-enrichment products with the introduction of HaloPlex exome kits and
SureCall software. 

The new additions are designed to complement Agilent`s Web-based SureDesign and
custom HaloPlex gene panels to provide a complete, integrated workflow. 

"These products simplify the sequencing of clinical research samples," said Olle
Ericsson, Agilent director of marketing for DNA sequencing. "The HaloPlex Exome
delivers streamlined capture of all coding exons, with low input sample
requirements, on all Illumina sequencing platforms. Together with SureDesign,
and the SureCall software, these products constitute a very comprehensive
clinical research solution for target enrichment." 

The HaloPlex exome kit comprises about 2.5 million probes to provide efficient
and comprehensive coverage of the coding regions of the human genome with
minimal hands-on time and requires only 200 ng of input DNA. 

"The HaloPlex exome provides an easy workflow for all-exon analysis enabling
short turnaround sequencing with low DNA input amounts," said Dr. Wilfred van
IJcken, assistant professor at Erasmus MC and an early access user who also will
present at the 14th annual Advances in Genome Biology and Technology meeting,
Feb. 20-23, in Marco Island, Fla. 

SureDesign, which has logged over 15,000 designs since it was launched in
October, enables clinical researchers to create a custom panel tailored to their
needs. With this interface, researchers can quickly generate exceptionally
flexible designs for high-performance, targeted resequencing, using Agilent's
HaloPlex and SureSelect systems. In just three simple steps, researchers can
create custom sequencing panels tailored to their specific projects. To provide
confidence in the analysis, any custom gene-sequencing panel can be created
based on the 2.5 million probes from the HaloPlex exome kit. 

SureCall data analysis software is designed to maximize clinical laboratory
throughput by dramatically simplifying the analysis workflow for next-generation
sequencing data. The software is fast, reliable and easy to use, with a
three-step workflow process that translates raw data into a report with genetic
variants classified and ranked in a matter of hours. Its end-to-end capabilities
make it more cost effective than other methods and enable clinical researchers
to focus on their results rather than cumbersome analysis processes by
eliminating the expensive, time-consuming data analysis bottleneck. To download
the new software free of charge, visit www.agilent.com/genomics/surecall. 

About Agilent in Genomics

Agilent a global leader in target enrichment for next-generation sequencing and
genomic microarrays. The Agilent SureSelect and HaloPlex target-enrichment
systems enable researchers to easily choose which segments of a genome to
sequence, avoiding the time and expense needed to sequence the entire genome.
HaloPlex and its same-day sample-to-sequencer workflow is well suited for
next-generation desktop sequencers, whereas SureSelect`s ability to accurately
capture whole exomes and whole methylomes in a single reaction pairs well with
high-throughput next-generation sequencing systems. These are just two products
arising from Agilent`s expertise in synthesizing custom complex mixtures of long
oligonucleotide gained in microarray manufacturing. Additional product lines
built on this core technology include microarrays for genome-wide measurement of
gene expression and for comparative genomics hybridization, as well as SureFISH,
a highly specific and sensitive oligonucleotide fluorescent in situ
hybridization product line. In addition to oligonucleotide-based products,
Agilent offers a microfluidic bioanalyzer to measure sample quality, a
target-enrichment tool to speed next-generation sequencing, and a full set of
reagents, hardware, methods and bioinformatics software for genomic experiments.


About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world`s premier measurement company
and a technology leader in chemical analysis, life sciences, diagnostics,
electronics and communications. The company`s 20,500 employees serve customers
in more than 100 countries. Agilent had revenues of $6.9 billion in fiscal 2012.
Information about Agilent is available at www.agilent.com. 

NOTE TO EDITORS: Further technology, corporate citizenship and executive news is
available at www.agilent.com/go/news.

Agilent Technologies Inc.
Eric Endicott, +1-408-553-2005
eric_endicott@agilent.com

Copyright Business Wire 2013

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