Acorda to Present New Research on Novel Multiple Sclerosis and Epilepsy Therapies at American Academy of Neurology 65th Annual Meeting

Wed Mar 13, 2013 7:00am EDT

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ARDSLEY, N.Y.--(Business Wire)--
Acorda Therapeutics, Inc. (Nasdaq: ACOR) will present new research data at the
65th American Academy of Neurology Annual Meeting on AMPYRA® (dalfampridine)
Extended Release Tablets, 10 mg, an FDA-approved therapy indicated to improve
walking in people with multiple sclerosis, and Diazepam Nasal Spray, an
investigational therapy for the treatment of cluster seizures, also known as
acute repetitive seizures, in people with epilepsy. 

"Acorda is focused on improving the lives of people with neurological disorders.
We currently are developing seven therapies for a range of conditions, including
multiple sclerosis, epilepsy and spinal cord injury," said Ron Cohen, M.D.,
Acorda Therapeutics` President and CEO. "Our presentations at AAN include new
studies on AMPYRA and the first clinical data presented on Diazepam Nasal Spray.
These studies have increased our understanding of the potential roles these
therapies could have in addressing the urgent needs of patients with these
conditions." 

Data being presented on Acorda-developed therapies at the AAN annual meeting
include:

* Changes in Gait, Walking, and Balance Parameters After Withdrawal and
Re-initiation of Dalfampridine Extended Release Tablets in Patients with
Multiple Sclerosis: Results from the STEADY Study - P04.103 being presented
Wednesday, March 20th, 7:30am - 12:00pm 
* Safety and Efficacy of 5mg and 10mg Dalfampridine Extended Release Tablets in
Patients with Multiple Sclerosis: First Results from a Double-Blind,
Placebo-Controlled Trial - P04.096 being presented Wednesday, March 20th, 7:30am
- 12:00pm 
* Effects of 5mg and 10mg Dalfampridine Extended Release Tablets on 6-Minute
Walk Distance in People with Multiple Sclerosis: A Subgroup Analysis of a
Double-Blind, Placebo-Controlled Trial - S01.007 being presented Tuesday, March
19th at 2:30pm 
* Assessment of Pharmacokinetic Linearity and Relative Bioavailability of a
Nasal Diazepam Formulation Compared with Diazepam Rectal Gel In Healthy Adult
Subjects - P02.214 being presented Tuesday, March 19th, 7:30am - 12:00pm

More detailed information on scientific sessions and data presentations at the
AAN annual meeting can be found on the conference website
(http://www.aan.com/go/am13). 

Important Safety Information

Do not take AMPYRA if you have ever had a seizure or have certain types of
kidney problems. 

Take AMPYRA exactly as prescribed by your doctor. 

You could have a seizure even if you never had a seizure before. Your chance of
having a seizure is higher if you take too much AMPYRA or if your kidneys have a
mild decrease of function, which is common after age 50. 

Your doctor may do a blood test to check how well your kidneys are working, if
that is not known before you start taking AMPYRA. 

AMPYRA may cause serious allergic reactions, including rare occurrence of
anaphylaxis. 

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP,
fampridine), since the active ingredient is the same. 

The most common adverse events for AMPYRA in MS patients were urinary tract
infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain,
and problems with balance. 

Before taking AMPYRA tell your doctor if you are pregnant or plan to become
pregnant. It is not known if AMPYRA will harm your unborn baby. 

Tell your doctor if you are breast-feeding or plan to breast-feed. It is not
known if AMPYRA passes into your breast milk. You and your doctor should decide
if you will take AMPYRA or breast-feed. You should not do both. 

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. 

About AMPYRA (dalfampridine)

AMPYRA is a potassium channel blocker approved as a treatment to improve walking
in patients with multiple sclerosis (MS). This was demonstrated by an increase
in walking speed. AMPYRA, which was previously referred to as Fampridine-SR, is
an extended release tablet formulation of dalfampridine (4-aminopyridine, 4-AP),
and is known as prolonged-, modified, or sustained-release fampridine (FAMPYRA®)
in some countries outside the United States (U.S.). 

In laboratory studies, dalfampridine extended release tablets has been found to
improve impulse conduction in nerve fibers in which the insulating layer, called
myelin, has been damaged. 

AMPYRA is being developed and commercialized in the U.S. by Acorda Therapeutics;
FAMPYRA is being developed and commercialized by Biogen Idec in markets outside
the U.S. based on a licensing agreement with Acorda. AMPYRA and FAMPYRA are
manufactured globally by Alkermes Pharma Ireland Limited, a subsidiary of
Alkermes plc, based on a supply agreement with Acorda. 

AMPYRA is available by prescription in the United States. For more information
about AMPYRA, including patient assistance and co-pay programs, healthcare
professionals and people with MS can contact AMPYRA Patient Support Services at
888-881-1918. 

AMPYRA Patient Support Services is available Monday through Friday, from 8:00
a.m. to 8:00 p.m. Eastern Time. For full U.S. Prescribing Information and
Medication Guide, please visit: www.AMPYRA.com. 

About Acorda Therapeutics

Acorda Therapeutics is a biotechnology company focused on developing therapies
that restore function and improve the lives of people with MS, spinal cord
injury and other neurological conditions. 

Acorda markets AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, in the
United States as a treatment to improve walking in patients with multiple
sclerosis (MS). This was demonstrated by an improvement in walking speed. AMPYRA
is marketed outside the United States as FAMPYRA® (prolonged-release fampridine
tablets) by Biogen Idec under a licensing agreement from Acorda. AMPYRA and
FAMPYRA are manufactured under license from Alkermes Pharma Ireland Limited. 

The Company also markets ZANAFLEX CAPSULES® (tizanidine hydrochloride) and
Zanaflex tablets, a short-acting drug for the management of spasticity. Acorda
also receives sales royalties on tizanidine hydrochloride capsules, an
authorized generic version of ZANAFLEX CAPSULES, distributed by Actavis, Inc.
under its agreement with Acorda. 

Acorda has an industry-leading pipeline of novel neurological therapies. The
Company is developing Diazepam Nasal Spray for treatment of certain epileptic
seizures. It is also studying AMPYRA to improve a range of functional
impairments caused by MS, as well as its potential for use in other neurological
conditions, including cerebral palsy and post-stroke deficits. In addition,
Acorda is developing clinical stage compounds AC105 for acute treatment of
spinal cord injury, GGF2 for treatment of heart failure and rHIgM22, a
remyelinating monoclonal antibody, for the treatment of MS. GGF2 is also being
investigated in preclinical studies as a treatment for neurological conditions
such as stroke and spinal cord injury. Chondroitinase, an enzyme that encourages
nerve plasticity in spinal cord injury, is in preclinical development. 

Acorda Forward-Looking Statements

This press release includes forward-looking statements within the meaning of the
Private Securities Litigation Reform Act of 1995. All statements, other than
statements of historical facts, regarding management's expectations, beliefs,
goals, plans or prospects should be considered forward-looking. These statements
are subject to risks and uncertainties that could cause actual results to differ
materially, including our ability to successfully market and sell Ampyra in the
U.S.; third party payers (including governmental agencies) may not reimburse for
the use of Ampyra or our other products at acceptable rates or at all and may
impose restrictive prior authorization requirements that limit or block
prescriptions; the risk of unfavorable results from future studies of Ampyra or
from our other research and development programs, including Diazepam Nasal Spray
or any other acquired or in-licensed programs; we may not be able to complete
development of, obtain regulatory approval for, or successfully market Diazepam
Nasal Spray or other products under development; the occurrence of adverse
safety events with our products; delays in obtaining or failure to obtain
regulatory approval of or to successfully market Fampyra outside of the U.S. and
our dependence on our collaboration partner Biogen Idec in connection therewith;
competition, including the impact of generic competition on Zanaflex Capsules
revenues; failure to protect our intellectual property, to defend against the
intellectual property claims of others or to obtain third party intellectual
property licenses needed for the commercialization of our products; failure to
comply with regulatory requirements could result in adverse action by regulatory
agencies; and the ability to obtain additional financing to support our
operations. These and other risks are described in greater detail in Acorda
Therapeutics' filings with the Securities & Exchange Commission. Acorda may not
actually achieve the goals or plans described in its forward-looking statements,
and investors should not place undue reliance on these statements.
Forward-looking statements made in this release are made only as of the date
hereof, and Acorda disclaims any intent or obligation to update any
forward-looking statements as a result of developments occurring after the date
of this release.

Acorda Therapeutics
Jeff Macdonald, 914-326-5232
jmacdonald@acorda.com

Copyright Business Wire 2013

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