SOUTH SAN FRANCISCO, Calif., April 1, 2013 (GLOBE NEWSWIRE) -- Talon Therapeutics, Inc.,
(OTCQB:TLON), today reported financial results for the fourth quarter and year ended December 31,
2012 Corporate Highlights
* FDA accelerated approval of Marqibo for the treatment of Philadelphia chromosome negative adult
acute lymphoblastic leukemia (ALL) patients in second or greater relapse or whose disease has
progressed following two or more prior lines of anti-leukemia therapy.
* Enrollment and dosing of the first patient in the Phase 3 confirmatory study of Marqibo, named
HALLMARQ, in adult patients with newly diagnosed Philadelphia chromosome negative ALL.
* Publication of the Marqibo RALLY Study in the Journal of Clinical Oncology (JCO).
Three Months Ended December 31, 2012 Unaudited Financial Results
For the three months ended December 31, 2012, the Company reported net income of $7.1 million and
deemed dividends on preferred stock of $3.2 million, which when combined, resulted in net income
applicable to common stockholders of $3.9 million, or $0.18 and $.02 per basic and diluted share,
respectively. The change in fair value of Talon's preferred stockholders' right to purchase
additional shares of Series A-3 preferred stock contributed $13.1 million, or $0.59 per share, of
total net income applicable to common stockholders for the three months ended December 31, 2012.
The change in fair value of Talon's preferred stockholders' right to purchase additional shares of
preferred stock is primarily driven by fluctuations in price of Talon's common stock. This
compares with a net loss of $1.7 million and deemed dividends on preferred stock of $1.0 million
for the three months ended December 31, 2011, which when combined, resulted in a net loss
applicable to common stockholders of $2.7 million, or $0.12 per share, for such 2011 period.
Total operating expenses for the three months ended December 31, 2012 were $5.3 million, compared
with $3.7 million for the three months ended December 31, 2011. Research and development expenses
were $2.7 million for the three months ended December 31, 2012, compared with $2.3 million for the
three months ended December 31, 2011. General and administrative expenses were $2.7 million for
the three months ended December 31, 2012, compared with $1.4 million for the three months ended
December 31, 2011.
Cash used in operations was $5.5 million for the three months ended December 31, 2012. As of
December 31, 2012, the Company had cash and cash equivalents of $3.0 million. Following the end of
the 2012 fiscal year, on January 11, 2013, the Company sold additional shares of its Series A-3
Preferred Stock, resulting in gross proceeds of $6.0 million.
Year Ended December 31, 2012 Financial Results
For the year ended December 31, 2012, the Company reported a net loss of $43.7 million and deemed
dividends on preferred stock of $21.1 million, which when combined, resulted in a net loss
applicable to common stockholders of $64.8 million, or $2.95 per share. The deemed dividends on
preferred stock attributed $0.96 per share to the total net loss applicable to common stockholders
for the year ended December 31, 2012. The change in fair value of Talon's preferred stockholders'
right to purchase additional shares of Series A-3 preferred stock contributed $18.1 million, or
$0.82 per share, of the total net loss applicable to common stockholders for the twelve months
ended December 31, 2012. This compares with a net loss of $18.8 million and deemed dividends on
preferred stock of $3.9 million, which when combined, resulted in a net loss applicable to common
stockholders of $22.8 million, or $1.06 per share for the year ended December 31, 2011.
Total operating expenses for the year ended December 31, 2012, were $20.8 million, compared with
$18.5 million for the year ended December 31, 2011. Research and development expenses were $12.9
million for the twelve months ended December 31, 2012, compared with $13.4 million for the year
ended December 31, 2011. General and administrative expenses were $7.9 million for the year ended
December 31, 2012, compared with $5.1 million for the year ended December 31, 2011.
Cash used in operations was $20.2 million for the year ended December 31, 2012.
About Marqibo (vincristine sulfate liposome injection)
Marqibo is a novel, targeted Optisome encapsulated formulation product candidate of the
FDA-approved anticancer drug vincristine. Talon is primarily developing Marqibo for the treatment
of Ph- adult ALL. Vincristine, a microtubule inhibitor, is FDA-approved for ALL and is widely used
as a single agent and in combination regimens for treatment for hematologic malignancies such as
lymphomas and leukemias. Talon's encapsulation formulation is designed to provide prolonged
circulation of the drug in the blood and accumulation at the tumor site. These characteristics are
intended to increase the dose of vincristine delivered in a safe and effective manner.
Talon has received orphan drug and fast track designations for Marqibo for the treatment of adult
ALL from the U.S. Food and Drug Administration. Marqibo has also received orphan drug designation
in adult ALL from the European Medicines Evaluation Agency.
Please see important safety information below and the full prescribing information for Marqibo at
Indication and usage
Marqibo is a liposomal vinca alkaloid indicated for the treatment of adult patients with
Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater
relapse or whose disease has progresses following two or more anti-leukemia therapies. This
indication is based on overall response rate. Clinical benefit such as improvement in overall
survival has not been verified.
Important safety information
* Marqibo is contraindicated in patients with demyelinating conditions including
* Marqibo is contraindicated in patients with hypersensitivity to vincristine sulfate or any of
the other components of Marqibo (vinCRIStine sulfate LIPOSOME injection
* Marqibo is contraindicated for intrathecal administration
See full prescribing information for complete boxed warning.
* For Intravenous Use Only -- Fatal if Given by Other Routes
* Death has occurred with intrathecal use
* Marqibo (vinCRIStine sulfate LIPOSOME injection) has different dosage recommendations than
vinCRIStine sulfate injection. Verify drug name and dose prior to preparation and administration
to avoid overdosage.
Warnings and Precautions
For Intravenous Use Only
For Intravenous use only. Fatal if given by other routes.
Extravasation Tissue Injury
Only administer through a secure and free-flowing venous access line. If extravasation is
suspected, discontinue infusion immediately and consider local treatment measures.
Sensory and motor neuropathies are common and are cumulative. Monitor patients for symptoms of
neuropathy, such as hypoesthesia, hyperesthesia, paresthesia, hyporeflexia, areflexia, neuralgia,
jaw pain, decreased vibratory sense, cranial neuropathy, ileus, burning sensation, arthralgia,
myalgia, muscle spasm, or weakness, both before and during treatment. Orthostatic hypotension may
occur. The risk of neurologic toxicity is greater if Marqibo is administered to patients with
preexisting neuromuscular disorders or when other drugs with risk of neurologic toxicity are being
given. In the studies of relapsed and/or refractory adult ALL patients, Grade >= 3 neuropathy
events occurred in 32.5% of patients. Worsening neuropathy requires dose delay, reduction, or
discontinuation of Marqibo.
Monitor complete blood counts prior to each dose of Marqibo. If Grade 3 or 4 neutropenia,
thrombocytopenia, or anemia develops, consider Marqibo dose modification or reduction as well as
supportive care measures.
Tumor Lysis Syndrome
Tumor lysis syndrome (TLS) may occur in patients with ALL receiving Marqibo. Anticipate, monitor
for, and manage.
Constipation and Bowel Obstruction
Ileus, bowel obstruction, and colonic pseudo-obstruction have occurred. Marqibo can cause
constipation. Institute a prophylactic bowel regimen to mitigate potential constipation, bowel
obstruction, and/or paralytic ileus, considering adequate dietary fiber intake, hydration, and
routine use of stool softeners, such as docusate. Additional treatments, such as senna, bisacodyl,
milk of magnesia, magnesium citrate, and lactulose may be considered.
Marqibo can cause severe fatigue. Marqibo dose delay, reduction, or discontinuation may be
Fatal liver toxicity and elevated levels of aspartate aminotransferase have occurred. Elevated
levels of aspartate aminotransferase of Grade >=3 occurred in 6-11% of patients in clinical
trials. Monitor hepatic function tests. Reduce or interrupt Marqibo for hepatic toxicity.
Marqibo can cause fetal harm when administered to a pregnant woman. Vincristine sulfate liposome
injection was teratogenic or caused embryo-fetal death in animals. Women of childbearing potential
should avoid becoming pregnant while being treated with Marqibo. There are no adequate and
well-controlled studies of Marqibo in pregnant women and there were no reports of pregnancy in any
of the clinical studies in the Marqibo clinical development program. If this drug is used during
pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be
apprised of the potential hazard to a fetus [see Use in Specific Populations].
The most common adverse reactions (>30%) were constipation (57%), nausea (52%), pyrexia (43%),
fatigue (41%), peripheral neuropathy (39%), febrile neutropenia (38%), diarrhea (37%), anemia
(34%), decreased appetite (33%), and insomnia (32%).
The most commonly reported SAEs included febrile neutropenia (20.5%), pyrexia (13.3%), hypotension
(7.2%), respiratory distress (6.0%), and cardiac arrest (6.0%).
Twenty-eight percent of patients experienced adverse reactions leading to treatment
discontinuation. The most common adverse reactions that caused treatment discontinuation were
peripheral neuropathy (10%), leukemia-related (7%), and tumor lysis syndrome (2%).
Deaths occurred in 23% of patients in study 1. The non-leukemia related causes of deaths were
brain infarct (1), intracerebral hemorrhage (2), liver failure (1), multi-system organ failure
(2), pneumonia and septic shock (3), respiratory failure (4), pulmonary hemorrhage (1), and sudden
cardiac death (1).
No formal drug interaction studies have been conducted with Marqibo. Marqibo is expected to
interact with drugs known to interact with non-liposomal vincristine sulfate.
Simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy
combinations that included non-liposomal vincristine sulfate has been reported to reduce blood
levels of phenytoin and to increase seizure activity.
Vincristine sulfate, the active agent in Marqibo, is a substrate for cytochrome P450 3A isozymes
(CYP3A); therefore, the concomitant use of strong CYP3A inhibitors should be avoided (e.g.,
ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, atazanavir, indinavir,
nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin). Similarly, the concomitant use of
strong CYP3A inducers should be avoided (e.g., dexamethasone, phenytoin, carbamazepine, rifampin,
rifabutin, rifapentine, phenobarbital, St. John's Wort).
Vincristine sulfate, the active agent in Marqibo, is also a substrate for P-glycoprotein (P-gp).
The effect of concomitant use of potent P-gp inhibitors or inducers has not been investigated; it
is likely that these agents will alter the pharmacokinetics or pharmacodynamics of Marqibo.
Therefore the concomitant use of potent P-gp inhibitors or inducers should be avoided.
Use in Specific Populations
Pregnancy Category D [see Warnings and Precautions]
Based on its mechanism of action and findings from animal studies, Marqibo can cause fetal harm
when administered to pregnant women.
If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug,
the patient should be apprised of the potential hazard to a fetus. In an embryofetal developmental
study, pregnant rats were administered vincristine sulfate liposome injection intravenously during
the period of organogenesis at vincristine sulfate doses of 0.022 to 0.09 mg/kg/day. Drug-related
adverse effects included fetal malformations (skeletal and visceral), decreases in fetal weights,
increased numbers of early resorptions and post-implantation losses, and decreased maternal body
weights Malformations were observed at doses >= 0.044 mg/kg/day in animals at systemic exposures
approximately 20-40% of those reported in patients at the recommended dose.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in
human milk and because of the potential for serious adverse reactions in nursing infants, a
decision should be made whether to discontinue nursing or discontinue the drug taking into account
the importance of the drug to the mother.
The safety and effectiveness of Marqibo in pediatric patients have not been established.
Safety and effectiveness in elderly individuals have not been established. In general, dose
selection for an elderly patient should be cautious, reflecting the greater frequency of decreased
hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
The influence of renal impairment on the safety, efficacy, and pharmacokinetics of Marqibo has not
Non-liposomal vincristine sulfate is excreted primarily by the liver. The influence of severe
hepatic impairment on the safety and efficacy of Marqibo has not been evaluated. The
pharmacokinetics of Marqibo was evaluated in patients with moderate hepatic dysfunction
(Child-Pugh B) secondary to melanoma liver metastases. The dose-adjusted maximum plasma
concentration (Cmax) and area under the concentration-time curve (AUC) of Marqibo in patients with
moderate hepatic impairment was comparable to the Cmax and AUC of patients with ALL who had
otherwise normal hepatic function.
About Talon Therapeutics
Talon Therapeutics, Inc. is a biopharmaceutical company dedicated to seizing upon medical
opportunities, efficiently and expertly leading product candidates through clinical development,
and transferring value to patients, patient care providers, shareholders, corporate partners, and
employees. In addition to Marqibo (vincCRIStine sulfate LIPOSOME injection) which received
accelerated approval from the US FDA in August 2012, Talon has additional pipeline opportunities
some of which like Marqibo, have the potential to improve delivery and enhance the therapeutic
benefits of well characterized, proven chemotherapies and enable high potency dosing without
Additional information on Talon Therapeutics can be found at www.talontx.com
This press release contains forward-looking statements within the meaning of the Private
Securities Litigation Reform Act of 1995. These statements are often, but not always, made through
the use of words or phrases such as "anticipates," "expects," "plans," "believes," "intends," and
similar words or phrases. Such statements involve risks and uncertainties that could cause Talon's
actual results to differ materially from the anticipated results and expectations expressed in
these forward-looking statements. These statements are based on current expectations, forecasts
and assumptions that are subject to risks and uncertainties, which could cause actual outcomes and
results to differ materially from these statements. Such risks and uncertainties include: Talon's
ability to commercialize Marqibo alone or with any strategic partner; the likelihood of completing
a strategic transaction; Talon's lack of experience commercializing pharmaceutical products; that
Talon will be able to secure the additional capital necessary to fund operational activities for
Marqibo, including its ongoing research and development programs to completion; Talon's reliance
on third-party clinical research organizations to develop its product candidates, and its lack of
experience in developing pharmaceutical products. Additional risks are described in the company's
Annual Report on Form 10-K for the year ended December 31, 2012. Talon assumes no obligation to
update these statements, except as required by law.
TALON THERAPEUTICS, INC.
December 31, December 31,
Cash and cash equivalents $ 2,973,028 $ 1,028,518
Inventory 283,321 -
Prepaid expenses and other current assets 237,918 635,297
Total current assets 3,494,267 1,663,815
Property and equipment, net 42,714 72,431
Restricted cash 34,004 -
Debt issuance costs, net 517,525 751,401
Total assets $ 4,088,510 $ 2,487,647
LIABILITIES AND STOCKHOLDERS' DEFICIT
Accounts payable and accrued liabilities $ 3,549,276 $ 4,556,951
Investors' rights to purchase shares of Series A-3 Preferred Stock 14,276,000 -
Other short term liabilities 2,474 2,110
Total current liabilities 17,827,750 4,559,061
Notes payable, net of discount 24,833,183 24,033,257
Investors' right to purchase future shares of Series A-1 and A-2 preferred stock - 1,772,100
Warrant liabilities, non-current 563,070 501,664
Other long term liabilities - 2,474
Total long term liabilities 25,396,253 26,309,495
Total liabilities 43,224,003 30,868,556
Redeemable convertible preferred stock; $0.001 par value:
10 million shares authorized, 0.7 million and 0.4 million shares issued and outstanding at December 31, 2012 and December 31, 2011, respectively; aggregate liquidation value of $77.9 million and $46.4 million at December 31, 2012 and December 31, 2011, respectively 47,913,500 30,643,219
Common stock; $0.001 par value:
600 million shares authorized, 22.0 million and 21.8 million shares issued and outstanding at December 31, 2012 and December 31, 2011, respectively 22,001 21,779
Additional paid-in capital 136,562,864 120,887,432
Accumulated deficit (223,633,858) (179,933,339)
Total stockholders' deficit (87,048,993) (59,024,128)
Total liabilities, redeemable convertible preferred stock and stockholders' deficit $ 4,088,510 $ 2,487,647
TALON THERAPEUTICS, INC.
STATEMENTS OF OPERATIONS
Three Months Ended Years Ended
December 31, December 31,
2012 2011 2012 2011
General and administrative $ 2,660,675 $ 1,398,422 $ 7,900,846 $ 5,121,678
Research and development 2,651,519 2,325,690 12,898,688 13,387,168
Total operating expenses 5,312,194 3,724,112 20,799,534 18,508,846
Loss from operations (5,312,194) (3,724,112) (20,799,534) (18,508,846)
Interest income 597 158 3,324 8,124
Interest expense (928,931) (900,112) (3,751,799) (3,560,444)
Other expense, net - (2,768) - (78,768)
Change in fair value of warrant liabilities 268,111 454,187 (73,151) (41,146)
Change in fair value of investors' right to purchase future shares of Series A-1 and A-2 preferred stock .- 2,522,900 (1,006,900) 3,358,900
Change in fair value of investors' right to purchase future shares of Series A-3 preferred stock 13,064,200 - (18,072,459) -
Total other income/(expense) 12,403,977 2,074,365 (22,900,985) (313,334)
Net income/(loss) $ 7,091,783 $ (1,649,747) $ (43,700,519) $ (18,822,180)
Deemed dividends attributable to preferred stock in connection with accretion (1,692,065) (1,028,307) (5,847,123) (3,947,713)
Deemed dividends attributable to preferred stock in connection with embedded conversion features (1,488,750) - (15,236,723) -
Net income/(loss) applicable to common stockholders $ 3,910,968 $ (2,678,054) $ (64,784,365) $ (22,769,893)
Net income/(loss) per share, basic $ 0.18 $ (0.12) $ (2.95) $ (1.06)
Weighted average shares used in computing net income/(loss) per share, basic 22,001,891 21,778,812 21,925,200 21,557,062
Net income/(loss) per share, diluted $ 0.02 $ (0.12) $ (2.95) $ (1.06)
Weighted average shares used in computing net income/(loss) per share, diluted 172,472,705 21,778,812 21,925,200 21,557,062
Talon Therapeutics, Inc.
Investor Relations Team