Court upholds $142 million verdict against Pfizer over Neurontin

Wed Apr 3, 2013 10:18pm EDT

A woman walks past the Pfizer Inc. headquarters in New York, January 31, 2013. REUTERS/Brendan McDermid

A woman walks past the Pfizer Inc. headquarters in New York, January 31, 2013.

Credit: Reuters/Brendan McDermid

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(Reuters) - A federal appeals court said Pfizer Inc should pay about $142 million to cover costs for the marketing and prescribing of epilepsy drug Neurontin for unapproved uses, a practice that has also earned it a hefty criminal fine.

A panel of appellate judges in Boston on Wednesday refused to overturn a ruling in favor of Kaiser Foundation Health Plan, which claimed it had been damaged after prescribing Neurontin for conditions it did not effectively treat, based on fraudulent marketing by Pfizer, the largest U.S. drugmaker.

In related appeals, the panel also revived similar claims from insurer Aetna and class action allegations from Harden Manufacturing Corp, restoring lawsuits that had been thrown out by a lower court.

The ruling in the Kaiser case, which deals the biggest immediate blow to Pfizer, upholds a lower court's decision not to grant Pfizer a new trial after a jury had awarded it $142 million.

The jury found that Pfizer had marketed Neurontin for bipolar disorder, migraines and neuropathic pain, none of which had been approved by the U.S. Food & Drug Administration.

The verdict followed a $240 million criminal fine in 2004 paid by Pfizer's Warner-Lambert unit, as well as a $190 million civil fine paid by Pfizer in connection with the off-label marketing.

Neurontin, developed by a Warner-Lambert unit, was approved in 1993 to treat seizures at a maximum dose of 1800 milligrams per day. Warner-Lambert was later acquired by Pfizer.

The drugmaker initially forecast about $500 million in revenue generated by Neurontin, but in 1995 began marketing it for off-label uses in an attempt to increase its earning potential -- a move that apparently worked, reaping $2 billion from Neurontin sales in 2003 alone, the appellate court said.

Pfizer marketed Neurontin for off-label uses directly to doctors, sponsored misleading informational supplements and suppressed negative information about the drug, the opinion said.

The company's internal marketing plan for certain drugs, including Neurontin, called for the development of relationships with Kaiser officials "who are not considered whistle blowers," according to the opinion.

In a statement, Kaiser said it was "very pleased" and that "justice has been achieved for our members and the physicians, pharmacists and staff who care for them." David Frederick, an attorney for Kaiser, said he was "gratified by the court's carefully crafted decision."

Pfizer was less satisfied, saying in a statement it believes "there was no basis in fact or law" for the awards in the Kaiser case.

In the Aetna and Harden cases, Pfizer said it believed the lower court's dismissals were the right move and that it "disagrees with the conclusions" of the appeals court.

"We are exploring our appellate options in all three of these cases," the company said.

Pfizer's attorneys in the case, from law firms Skadden Arps Slate Meagher & Flom and Quinn Emanuel Urquhart & Sullivan, could not be reached.

The Kaiser cases are Kaiser Foundation Health Plan et al v. Pfizer Inc et al, U.S. Court of Appeals for the First Circuit, Nos. 11-1904 and 11-2096.

(Reporting by Nick Brown; Editing by Stephen Coates)

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Comments (2)
nocroman wrote:
Question? what penalty is the Veterans Administration going to pay us veterans whom they prescribed and distibuted Neurontin Via persciption.I was prescibed Nuerontin by a VA Neurologist for Diabetic Neuropathy.

This goes the same way as Quinine sulfate which was also prescribed and given to veterans to aliviate severe muscle cramps due to lack of blood flow and diabetic neuropathy.
Suddenly we were told they had to stop prescibing quinine sulfate as it was not approved by the FDA for use of our medical problems and it did not matter if it worked or not. I was given another drug that works about 1/5th as well as the quinine sulfate did.

This 100% disabled veteran that lives his life in 24/7 pain says, license drugs for what the compnay says it is supposed to treat, BUT, if it is found to do other things that help patients with other medical problems, then add on to the list as newly discovered medical uses for that drug, and stop banning good drugs just because some one didn’t file or know all the uses that drug would be good for.

Apr 04, 2013 1:46am EDT  --  Report as abuse
nocroman, your doctor is wrong if he or she is telling you that a drug cannot be prescribed to you simply because it was FDA approved for something else. Doctors can and do prescribe drugs for off-label uses all the time. The issue in this case is that Pfizer cannot advertise their drug as treating diseases A and B if it was only approved for treatment of disease C.

You should see your doctor, say that the old drugs you were previously on worked better and that you want them back. If the doc tells you it’s illegal because the drugs were not approved for that purpose, find a new doctor.

Apr 04, 2013 10:05pm EDT  --  Report as abuse
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