UPDATE 5-Work on "cell traffic" and disease triggers wins Nobel prize

Mon Oct 7, 2013 11:02am EDT

By Niklas Pollard

STOCKHOLM Oct 7 (Reuters) - Three U.S.-based scientists won the Nobel medicine prize on Monday for plotting how vital materials such as hormones and brain chemicals are transported within cells and secreted to act on the body, giving insight into diseases such as diabetes and Alzheimer's.

Americans James Rothman, 62, Randy Schekman, 64, and German-born Thomas Suedhof, 57, separately mapped out one of the body's critical networks that uses tiny bubbles known as vesicles to ferry chemicals such as insulin within cells.

The system, which also describes how vesicles transport molecules to the cell surface for secretion, is so critical and sensitive that errors and disruption in the mechanism can lead to serious illness or death.

"Without this wonderfully precise organisation, the cell would lapse into chaos," the Nobel Assembly at Sweden's Karolinska Institute said in a statement when awarding the prize of 8 million crowns ($1.2 million).

"Through their discoveries, Rothman, Schekman and Suedhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo."

For example, their research sheds light on how insulin, which controls blood sugar levels, is manufactured and released into the blood at the right place at the right time, the Nobel committee said in the statement.

Diabetes and some brain disorders have been attributed at least in part to defects in the vesicle transport systems.

Rothman is professor at Yale University, Schekman is a professor at the University of California at Berkeley, while Suedhof is a professor at Stanford University. The three, working separately, adopted quite different approaches to the problem, reflecting their own scientific specialisms.

"HOW CELLS WORK"

"My first reaction was, "Oh, my god!" said Schekman, who was woken with the good news in the early hours of his morning. "That was also my second reaction," he added, according to a Berkeley University statement.

Suedhof, a U.S. citizen, professed similar surprise.

"It blew me over," he told Reuters. "Every scientist dreams of getting a Nobel prize. It's something I often tell my kids. If you lose your dreams you lose your reason to live."

Medicine is the first of the Nobel prizes awarded each year. Prizes for achievements in science, literature and peace were first awarded in 1901 in accordance with the will of dynamite inventor and businessman Alfred Nobel.

Suedhof said the work was really about "cell traffic", the ability of cells to move material around.

"We have met each other many many times and argued and sometimes agreed and sometimes disagreed," he said of his fellow prize winners. "We really work in quite distinct areas of science."

Professor Patrik Rorsman of Oxford University said the award was timely and well deserved. "It is such a fundamental process they have studied and explained.

"Their discoveries could perhaps have clinical implications in psychiatric diseases, but my guess is that they will be more useful for the understanding of how cells work."

The committee said the work could help in understanding immuno-deficiency, as well as brain disorders such as autism.

Schekman, a geneticist, first became interested in how proteins move within cells in 1974. At the University of California, Berkeley, he began working on yeast, a single cell microorganism. Research showed his findings applied equally to human cells

Among Schekman's research aims is to study whether the accumulation of the protein amyloid in the brains of Alzheimer's disease patients is due to disruption of the vesicle system.

Suedhof, a neuroscientist, has focused particularly on the brain and questions of human thought and perception, emotions and actions determined by signaling between neurons, cells which constitute the foundation of the nervous system.

"I'm interested in understanding how is it possible for one cell to talk to the other ... This field is one of the most fundamental fields involved in understanding how the brain works, which is one of the most important questions in biology today."

Jeremy M. Berg, director of the Institute for Personalized Medicine at the University of Pittsburgh, said the research had tackled key questions of how molecules are directed by vesicles to the cell wall and secreted to act on the body.

"You can't understand anything about how the brain works without understanding this process. You can't understand anything about hormone secretion without understanding this process.

"It's one of the prizes for which there is not a treatment that came out of it directly, but there are probably literally thousands of laboratories around the world whose work would not be taking place the way it is without their work."

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