Relapse of 'cured' HIV patients spurs AIDS science on

LONDON Thu Jan 2, 2014 5:21am EST

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LONDON (Reuters) - Scientists seeking a cure for AIDS say they have been inspired, not crushed, by a major setback in which two HIV positive patients believed to have been cured found the virus re-invading their bodies once more.

True, the news hit hard last month that the so-called "Boston patients" - two men who received bone marrow transplants that appeared to rid them completely of the AIDS-causing virus - had relapsed and gone back onto antiretroviral treatment.

But experts say the disappointment could lay the basis for important leaps forward in the search for a cure.

"It's a setback for the patients, of course, but an advance for the field because the field has now gained a lot more knowledge," said Steven Deeks, a professor and HIV expert at the University of California, San Francisco.

He and other experts say the primary practical message is that current tests designed to detect even very low levels of HIV present in the body are simply not sensitive enough.

As well as having the human immunodeficiency virus (HIV), the Boston patients both also had a type of blood cancer called lymphoma, for which they were treated using bone marrow transplants - one man in 2008 and the other in 2010.

They continued taking the antiretroviral AIDS drugs, but eight months after each patient's transplant, doctors found they could not detect any sign of HIV in their blood.

In the early part of 2013, both patients decided to stop taking their AIDS drugs and both appeared to remain HIV-free - prompting their doctors, Timothy Henrich and Daniel Kuritzkes from Boston's Brigham and Women's Hospital, to announce at a conference in July that they may have been cured.

Yet in December came news that one of the men had begun to show signs of an HIV rebound by August, while the second patient had a relapse in November.

Henrich said the virus' comeback underlined how ingenious HIV can be in finding hiding places in the body to evade attack efforts by the immune system and by drug treatment.

"Through this research we have discovered the HIV reservoir is deeper and more persistent than previously known and that our current standards of probing for HIV may not be sufficient," he said, adding that both patients were "currently in good health" and back on antiretroviral therapy.

INSPIRATION

Barely a decade ago, few HIV scientists would have dared put the words HIV and cure in the same sentence. Yet some intriguing and inspiring cases in recent years mean many now believe it is just a question of time before a cure is found.

First was the now famous case of Timothy Ray Brown, the so-called "Berlin patient," whose HIV was eradicated by a complex treatment for leukemia in 2007 involving the destruction of his immune system and a stem cell transplant from a donor with a rare genetic mutation that resists HIV infection.

Such an elaborate, expensive and life-threatening procedure could never be used as a broad-spectrum approach for the world's 34 million HIV patients. But the results in Brown focused scientific attention on a genetic mutation known as 'CCR5 delta 32' as a target for possible gene therapy treatment.

Then last March, French scientists who followed 14 HIV-positive people known as the "Visconti patients", who were treated very swiftly with HIV drugs but then stopped treatment, said that even after seven years off therapy, they were still showing no signs of the virus rebounding.

That announcement came only weeks after news of the "functional cure" of an HIV-positive baby in Mississippi who received antiretroviral treatment for 18 months from the day she was born. By the time she was two this appeared to have stopped the virus replicating and spreading.

A "functional cure" is when HIV is reduced to such low levels that it is kept at bay even without treatment, though the virus can still be detected in the body.

Sharon Lewin, an HIV expert at Monash University in Australia, said all these developments, as well as the setback suffered by the Boston patients, inspired scientists to investigate many different approaches in the search for a cure.

"We've learnt many things here - and one of the most important is that a tiny, tiny amount of virus can get the whole thing going again," she told Reuters. "It's a clear message that we need better ways to pick up the virus."

Scientists are now more convinced than ever that a two-pronged approach which aims to firmly suppress the virus while bolstering the immune system provides the best way forward.

"We need to attack in two ways - reduce the virus to very low levels and also to boost the immune response. We can't do one without the other," said Lewin.

"So we still have to think of other creative ways to control HIV. And it's still early days... before we can say which approach is likely to be the winner."

(Reporting by Kate Kelland, editing by Gareth Jones)

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Comments (6)
UrDrighten wrote:
It’s odd that a virus that infects at least 34 million people cannot be treated with a vaccine as we do other viruses, such as influenza, polio, smallpox,and rabies.

Surely HIV cannot be mutating so very quickly that no one can make a working vaccine?

Well, something to think about…

Jan 02, 2014 11:21am EST  --  Report as abuse
As far as Drugs and Vaccinations are concerned, science has already proven they are dangerous to your good health and most of the AIDS drugs do as much harm as AIDS, which some scientist have already admitted.

The Cure for AIDS is in the destruction of the Enzyme Reverse Transcriptase, which is needed to replicate the virus and in the Mid-1990′s science found a substance within the Olive Leaf which actually prevents the Reverse Transcriptase from replicating. The problem is Olive Leaf extract can not be Patented, so a synthetic source is their solution for a profitable cure for this Man-Made Disease. UMOJA Research some facts below.

In the Monday May 11, 1987 London Times article, Science Editor Pearce Write’s headlines were, “Smallpox Vaccine “Triggered AIDS Virus” and the WHO was giving the medical injections.

Dr. William Campbell Douglas, M.D., wrote a paper titled, “WHO Murdered Africa” and suggested WHO was not a question, but the World Health Organization was responsible for AIDS in Africa.

Robert B. Strecker M.D, PhD and his brother, Attorney Theodore Strecker, presented the documented facts on the Request, Production and Distribution AIDS and presented WHO documents suggesting their possible involvement in the intentional spread of AIDS in Africa, in a DVD titled, “The Strecker Memorandum” and a document complete with references presented to every U.S. Government Agency titled, “This Is A Bio-Attack Alert, dated March 28, 1986.

Additional scientific evidence of the creation and intentional spread of AIDS was given by Dr. John Seale, a member of the Royal College of Medicine in London and an in depth description of Dr. Seale’s documented evidence on the creation of AIDS was written by Dr. Gary L. Glum in a book titled, “Full Disclosure”.

The two herbs being used are Olive Leaf Extract and the Native American Herb Chaparral, along with supplements to enhance the Immune System, Raw Vegetables and Raw Fruit Juices. The Raw Diet offers the body Enzymes to help restore the Immune System, no meat and no microwave food; microwave food goes through a molecular change from the microwaves.

People who have returned to work were on the Raw Food and Herbs. Read The Persecution Of Gaston Naessens. Gaston Naessens of Canada used a product he calls 714-X, which unclogs the Lymphatic System. In Court he testified he never said he cured Cancer or AIDS, he said 714-X clears the Lymphatic System and the body heals itself. Many people cured of Cancer and AIDS testified in his defense and he won his case. 714-X is banned in the USA.

Kemron, which was being used successfully by the doctors of the Nation Of Islam, was also banned. The reason Kemron worked is because it helped the body to naturally produce hydrogen peroxide. Hydrogen Peroxide destroys all anaerobic bacteria and viruses. (look for the book “Oxygen Therapy” by Ed McCabe, oxygenhealth.com)

The number of Doctors, Virologists, Medical Researchers and other Scientists working in the best interest of Humanity are growing and they are telling the chilling Truth About AIDS.

It should also be noted, the natural remedies which have been proven by science to be effective against AIDS are suppressed, because the Herbs and Raw Diets cost pennies on the dollar and cannot be patented by drug companies.

Ref: 


1. Politics in Healing: The Suppression and Manipulation of American Medicine by Daniel Haley

2. The Persecution and trial of Gaston Naessens: The True Story of The Efforts to Suppress an Alternative Treatment for Cancer, AIDS and Other Immunologically Based Diseases, by Christopher Bird.


3. DVD, The Strecker Memorandum, Robert B. Strecker MD, PhD.


4. Olive Leaf Extract, by Morton Walker.


5. Smallpox Vaccine “Triggered AIDS Virus”, Pearce Wright, Science Editor, London Times, Monday May 11, 1987


6. WHO Murdered Africa, by William Campbell Douglas, M.D. There is no question mark after the title of this article because the title is not a question.


7. DVD, VACCINES, What CDC Documents and Science Reveal, by Dr. Sherri J. Tenpenny


8. This Is A Bio-Attack Alert, by Robert B Strecker MD, PhD, Attorney Theodore A Strecker, written March 28, 1986 and submitted to every U.S. Government Agency.

9. “Full Disclosure”, by Dr. Gary L Glum (AIDS Evidence of Dr. John Seale
10. Nutrition Against Disease, Roger J. Williams

11. Racketeering in Medicine, The Suppression of Alternatives, James P. Carter, M.D., Dr.P.H

12. DVD, Cancer The Forbidden Cures, Massimo Mazzucco

13. DVD, Dying To Have Known, The Evidence Behind Natural Healing, Steve Kroschel
14. Murder By Injection: The Story of The Medical Conspiracy Against America, by Eustace Mullins
15. The Trillion-Dollar Conspiracy: How The New World Order, Man-Made Diseases and Zombie Banks Are Destroying America, by Jim Marrs
16. The Great Bird Flu Hoax: The Truth They Don’t Want You To Know About the “Next Big Pandemic”, by Dr. Joseph Mercola

Jan 02, 2014 12:55pm EST  --  Report as abuse
As far as Drugs and Vaccinations are concerned, science has already proven they are dangerous to your good health and most of the AIDS drugs do as much harm as AIDS, which some scientist have already admitted.

The Cure for AIDS is in the destruction of the Enzyme Reverse Transcriptase, which is needed to replicate the virus and in the Mid-1990′s science found a substance within the Olive Leaf which actually prevents the Reverse Transcriptase from replicating. The problem is Olive Leaf extract can not be Patented, so a synthetic source is their solution for a profitable cure for this Man-Made Disease. UMOJA Research some facts below.

In the Monday May 11, 1987 London Times article, Science Editor Pearce Write’s headlines were, “Smallpox Vaccine “Triggered AIDS Virus” and the WHO was giving the medical injections.

Dr. William Campbell Douglas, M.D., wrote a paper titled, “WHO Murdered Africa” and suggested WHO was not a question, but the World Health Organization was responsible for AIDS in Africa.

Robert B. Strecker M.D, PhD and his brother, Attorney Theodore Strecker, presented the documented facts on the Request, Production and Distribution AIDS and presented WHO documents suggesting their possible involvement in the intentional spread of AIDS in Africa, in a DVD titled, “The Strecker Memorandum” and a document complete with references presented to every U.S. Government Agency titled, “This Is A Bio-Attack Alert, dated March 28, 1986.

Additional scientific evidence of the creation and intentional spread of AIDS was given by Dr. John Seale, a member of the Royal College of Medicine in London and an in depth description of Dr. Seale’s documented evidence on the creation of AIDS was written by Dr. Gary L. Glum in a book titled, “Full Disclosure”.

The two herbs being used are Olive Leaf Extract and the Native American Herb Chaparral, along with supplements to enhance the Immune System, Raw Vegetables and Raw Fruit Juices. The Raw Diet offers the body Enzymes to help restore the Immune System, no meat and no microwave food; microwave food goes through a molecular change from the microwaves.

People who have returned to work were on the Raw Food and Herbs. Read The Persecution Of Gaston Naessens. Gaston Naessens of Canada used a product he calls 714-X, which unclogs the Lymphatic System. In Court he testified he never said he cured Cancer or AIDS, he said 714-X clears the Lymphatic System and the body heals itself. Many people cured of Cancer and AIDS testified in his defense and he won his case. 714-X is banned in the USA.

Kemron, which was being used successfully by the doctors of the Nation Of Islam, was also banned. The reason Kemron worked is because it helped the body to naturally produce hydrogen peroxide. Hydrogen Peroxide destroys all anaerobic bacteria and viruses. (look for the book “Oxygen Therapy” by Ed McCabe, oxygenhealth.com)

The number of Doctors, Virologists, Medical Researchers and other Scientists working in the best interest of Humanity are growing and they are telling the chilling Truth About AIDS.

It should also be noted, the natural remedies which have been proven by science to be effective against AIDS are suppressed, because the Herbs and Raw Diets cost pennies on the dollar and cannot be patented by drug companies.

Ref: 


1. Politics in Healing: The Suppression and Manipulation of American Medicine by Daniel Haley

2. The Persecution and trial of Gaston Naessens: The True Story of The Efforts to Suppress an Alternative Treatment for Cancer, AIDS and Other Immunologically Based Diseases, by Christopher Bird.


3. DVD, The Strecker Memorandum, Robert B. Strecker MD, PhD.


4. Olive Leaf Extract, by Morton Walker.


5. Smallpox Vaccine “Triggered AIDS Virus”, Pearce Wright, Science Editor, London Times, Monday May 11, 1987


6. WHO Murdered Africa, by William Campbell Douglas, M.D. There is no question mark after the title of this article because the title is not a question.


7. DVD, VACCINES, What CDC Documents and Science Reveal, by Dr. Sherri J. Tenpenny


8. This Is A Bio-Attack Alert, by Robert B Strecker MD, PhD, Attorney Theodore A Strecker, written March 28, 1986 and submitted to every U.S. Government Agency.

9. “Full Disclosure”, by Dr. Gary L Glum (AIDS Evidence of Dr. John Seale
10. Nutrition Against Disease, Roger J. Williams

11. Racketeering in Medicine, The Suppression of Alternatives, James P. Carter, M.D., Dr.P.H

12. DVD, Cancer The Forbidden Cures, Massimo Mazzucco

13. DVD, Dying To Have Known, The Evidence Behind Natural Healing, Steve Kroschel
14. Murder By Injection: The Story of The Medical Conspiracy Against America, by Eustace Mullins
15. The Trillion-Dollar Conspiracy: How The New World Order, Man-Made Diseases and Zombie Banks Are Destroying America, by Jim Marrs
16. The Great Bird Flu Hoax: The Truth They Don’t Want You To Know About the “Next Big Pandemic”, by Dr. Joseph Mercola

Jan 02, 2014 12:55pm EST  --  Report as abuse
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