* Breast-cancer tests enter late-stage with RESILIENCE trial
* Decision based on 2009 results of Phase II trial
* Bayer shares unchanged
(Adds details, background)
FRANKFURT, Feb 24 Bayer (BAYGn.DE) and Onyx
Pharmaceuticals ONXX.O have started recruiting breast-cancer
patients to start the third and last stage of testing their
Nexavar pill, a key pipeline drug for both drugmakers.
The Phase III trial dubbed RESILIENCE will compare women
receiving anti-cancer drug Nexavar in combination with standard
chemotherapy Xeloda to a control group receiving Xeloda and a
The trial participants are suffering from breast cancer that
has started spreading to other parts of the body.
In July 2009, Bayer and partner Onyx said that in a Phase II
study, Nexavar showed promise in treating breast tumours, the
second-most common form of cancer, sending Onyx shares soaring.
Xeloda is sold by Switzerland's Roche Holding ROG.VX.
Nexavar, already approved to treat kidney and liver tumours
in Europe, Asia and North America, is one of Bayer's most
promising new drugs, and Bayer has said it expects the drug to
generate combined annual sales of more than 2 billion euros
(Reporting by Ludwig Burger)