Industry-backed drug studies yield rosier findings

By Will Dunham

WASHINGTON (Reuters) - Breast cancer studies funded by drug companies are more likely to yield positive findings than those without pharmaceutical industry backing, according to research published on Monday.

A team led by Dr. Jeffrey Peppercorn of the University of North Carolina School of Medicine also found industry-backed studies tended to be designed differently than the others, but he said drug companies may simply be backing the least-risky alternatives.

The study was the latest to find industry-funded research producing more positive results. There are similar findings on heart, stroke and bone marrow cancer research.

Consumer advocates said the findings raised fresh questions about the integrity of company-funded research as the industry spends billions of dollars annually to bring new, potentially lucrative drugs to the market. The industry denied that studies were rigged to produce positive findings.

The researchers looked at 140 studies published in 2003, 1998 and 1993 in 10 medical journals on breast cancer therapies, nearly half of which were deemed to have had drug company involvement in the form of funding, provision of drugs or participation of a company scientist.

They focused their findings on 2003 because it was harder to determine industry involvement in the earlier studies.

In 2003, 58 percent of the studies had industry backing. Of these, 84 percent showed positive results, compared to 54 percent for other studies.

Peppercorn said there are several potential explanations.