Researchers show Alzheimer's, Glaucoma link

By Michael Kahn

LONDON (Reuters) - A protein that damages tissue in the brains of Alzheimer's patients is also the main cause of blindness worldwide, British researchers said in a new finding that may lead to better treatment for both diseases.

In a study published in the U.S. journal, Proceedings of the National Academy of Sciences, on Monday the scientists said the same protein, beta-amyloid, which plays a key role in the brain-wasting illness also causes nerve cell damage in the eye from blindness-inducing glaucoma.

Recent studies have suggested connections between Alzheimer's and glaucoma and the new finding bolsters that evidence, said Francesca Cordeiro, a glaucoma specialist at London's University College and leader of the study.

"This is the first time anybody has provided evidence that the same protein in Alzheimer's causes retinal nerve cell loss," she said in a telephone interview.

Scientists do not know what causes glaucoma which affects some 65 million people worldwide.

Most treatments seek to lower the build-up in pressure from fluids in the eye, but the treatment does not work for as many as 30 percent of glaucoma patients, Cordeiro said.

She hoped the study of laboratory rats would lead to an alternative treatment for humans one day.

After the team identified the protein link between the two diseases, they administered a combination of experimental Alzheimer's drugs to laboratory rats, Cordeiro said.