Mid-life high cholesterol raises Alzheimer's risk

By Will Dunham

WASHINGTON (Reuters) - High cholesterol levels in your 40s may raise the chance of developing Alzheimer's disease decades later, according to a study underscoring the importance of health factors in middle age on risk for the brain ailment.

The study involving 9,752 people in northern California found that those with high cholesterol levels between ages 40 and 45 were about 50 percent more likely than those with low cholesterol levels to later develop Alzheimer's disease.

The findings were presented on Wednesday at a meeting of the American Academy of Neurology in Chicago.

"Alzheimer's disease does not happen overnight," Dr. Alina Solomon of the University of Kuopio in Finland, who helped lead the study, said in a telephone interview.

"Alzheimer's disease has a very long preclinical phase -- a silent phase -- when you don't see any signs of the disease, but the disease is there. The pathological changes in the brain can sometimes develop over decades."

Alzheimer's disease is the most common form of dementia among older people, and researchers have been working to understand its causes and risk factors.

The findings come just weeks after another study showed that having a big belly in middle age may greatly increase one's risk of later developing Alzheimer's disease or another form of dementia.

Rachel Whitmer of the Kaiser Permanente Division of Research in Oakland, California who led that study also was involved in the new one on cholesterol levels.