Erbitux adds 5 weeks to lung cancer survival

By Deena Beasley

CHICAGO (Reuters) - Lung cancer patients treated in a large clinical trial with ImClone Systems Inc's Erbitux and chemotherapy lived about five weeks longer than patients treated with chemotherapy alone, according to study results released on Saturday.

"It's a modest improvement in survival," said Dr. Roy Herbst, chief of thoracic oncology at MD Anderson Cancer Center in Houston.

The findings were announced at a meeting here of the American Society of Clinical Oncology.

The 1,125-patient trial, sponsored by ImClone's European marketing partner Merck KGaA, showed that overall survival was 11.3 months for patients on the combination therapy, compared with 10.1 months for the group receiving just chemotherapy.

Lung cancer kills 1.3 million globally a year, according to the World Health Organization. The American Cancer Society says the disease was diagnosed in 213,380 people in the United States last year, killing 160,390.

The Erbitux partners previously said the study was successful but analysts and clinicians have been eager to see the full results in order to make comparisons with Genentech Inc's Avastin, which is so far the only nonchemotherapy drug approved as an initial treatment for non-small cell lung cancer, the most common form of the disease.

"I think that is a solid result. Wall Street was looking for a survival benefit of four to six weeks," said Cowen & Co analyst Eric Schmidt. "This is going to drive a lot of use."

A pivotal trial of Avastin, which excluded certain patient groups including those with squamous cell cancer, showed it boosted lung cancer survival by about eight weeks.