- IMO-2125 Induces Endogenous Interferons and Other Antiviral Proteins-
CAMBRIDGE, Mass.--(Business Wire)--
Idera Pharmaceuticals, Inc. (Nasdaq: IDRA) today presents preclinical data on
the mechanism by which IMO-2125 was shown to induce immune activation through
Toll-like Receptor 9 (TLR9). Two presentations are being made today at the 60th
Annual Meeting of the American Association for the Study of Liver Diseases being
held in Boston, MA.
"Induction of endogenous interferon-alpha and other antiviral proteins by
IMO-2125 provides a novel immunotherapy approach to the potential treatment of
chronic hepatitis C virus infection," said Sudhir Agrawal, D.Phil., Chief
Executive Officer and Chief Scientific Officer. "We currently are evaluating
IMO-2125 in two phase 1 clinical trials involving HCV patients non-responsive to
standard of care treatment and patients who are treatment-naïve. Data from these
clinical trials will guide decisions for further development of IMO-2125."
"One of our presentations today provides insights into the mechanism of immune
activation by IMO-2125 as mediated through TLR9 and the associated interferon
signaling pathways involving MyD88 and IRF7," said Tim Sullivan, Ph.D., Vice
President of Development Programs. "We also are presenting data that show
endogenous interferon-alpha induced by IMO-2125 exerts potent anti-HCV activity
in replicon assays. This activity is augmented by other cytokines induced by
IMO-2125."
Abstract 1593: "IMO-2125, a TLR9 agonist, induces Th-1 type cytokines and
interferons with potent anti-HCV activity in human peripheral blood mononuclear
cells (PBMCs) and plasmacytoid dendritic cells (pDCs)"
In this study, IMO-2125 induction of cytokines was evaluated in human peripheral
blood mononuclear cells (hPBMCs) and plasmacytoid dendritic cells (pDCs). The
data show that IMO-2125 induced high levels of endogenous interferon-alpha along
with interferon-beta, interferon-lambda, and other proteins including IP-10 and
2`-5`-OAS. These IMO-2125-induced cytokines showed potent antiviral activity in
the HCV replicon assay. Antiviral activity was decreased by addition of
anti-interferon-alpha antibody, but only partially which suggests that other
cytokines and chemokines induced by IMO-2125 also contribute to the antiviral
activity.
Abstract 1597: "Gene expression profiles induced by IMO-2125, an agonist of
Toll-like receptor 9, in human peripheral blood mononuclear cells"
In this study, the mechanism of immune activation by IMO-2125 in hPBMCs was
evaluated by gene expression analysis. Gene expression profiles were obtained
using TLR signaling pathway microarray, IFN-alpha/beta response microarray,
human innate and adaptive immune response microarray, and human Th1-Th2-Th3
response microarray. The results show that IMO-2125 mediated immune responses
through TLR9 and associated interferon signaling pathways involving MyD88 and
interferon regulatory factor 7 (IRF7). In addition, many type 1
interferon-response genes, interferon-inducible proteins, antiviral proteins,
TLR9 signaling molecules and transcription factors were up-regulated.
The above presentations are being made by Idera scientists today at 8:00 a.m.
ET.
About IMO-2125
IMO-2125 is a novel DNA-based TLR9 agonist being evaluated for the treatment of
chronic HCV infection. IMO-2125 has been shown to induce endogenous
interferon-alpha and other antiviral immune response proteins in preclinical
models, including non-human primates. IMO-2125 is being evaluated in a phase 1
clinical trial as monotherapy in patients with chronic HCV infection who have
failed to respond to previous standard of care combination therapy of ribavirin
and pegylated interferon-alpha. IMO-2125 also is being evaluated in a phase 1
clinical trial in combination with ribavirin in treatment-naïve patients with
chronic HCV infection.
About Idera Pharmaceuticals, Inc.
Idera Pharmaceuticals develops drug candidates to treat infectious diseases,
autoimmune and inflammatory diseases, cancer, and respiratory diseases, and for
use as vaccine adjuvants. Our proprietary drug candidates are designed to
modulate specific Toll-like Receptors (TLRs), which are a family of immune
system receptors that direct immune system responses. Our pioneering DNA and RNA
chemistry expertise enables us to create drug candidates for our internal
development programs and our partnered programs, and generates opportunities for
additional collaborative alliances. For more information, visit
www.iderapharma.com.
Idera Forward Looking Statements
This press release contains forward-looking statements concerning Idera
Pharmaceuticals, Inc. that involve a number of risks and uncertainties. For this
purpose, any statements contained herein that are not statements of historical
fact may be deemed to be forward-looking statements. Without limiting the
foregoing, the words "believes," "anticipates," "plans," "expects," "estimates,"
"intends," "should," "could," "will," "may," and similar expressions are
intended to identify forward-looking statements. There are a number of important
factors that could cause Idera's actual results to differ materially from those
indicated by such forward-looking statements, including whether results obtained
in preclinical studies, such as the studies referred to above, will be
indicative of results obtained in future clinical trials; whether products based
on Idera's technology will advance into or through the clinical trial process on
a timely basis or at all and receive approval from the United States Food and
Drug Administration or equivalent foreign regulatory agencies; whether, if the
Company's products receive approval, they will be successfully distributed and
marketed; whether the patents and patent applications owned or licensed by the
Company will protect the Company`s technology and prevent others from infringing
it; whether Idera's cash resources will be sufficient to fund the Company's
operations; and such other important factors as are set forth under the caption
"Risk Factors" in Idera's Quarterly Report on Form 10-Q for the three months
ended June 30, 2009, which important factors are incorporated herein by
reference. Idera disclaims any intention or obligation to update any
forward-looking statements.
Idera Pharmaceuticals, Inc.
Kelly Luethje, 617-679-5519
kluethje@iderapharma.com
or
MacDougall Biomedical Communications
Chris Erdman, 781-235-3060
cerdman@macbiocom.com
Copyright Business Wire 2009
