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Hollis-Eden says cancer drug candidate shows promise in study

Thu Oct 4, 2007 9:15am EDT

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Oct 4 (Reuters) - Hollis-Eden Pharmaceuticals Inc (HEPH.O) said its cancer drug candidate, HE3235, showed promise in a preclinical study involving animals injected with human prostate cancer cells.

Shares of the San Diego, California-based company were up more than 35 percent at $2.85 in early electronic trade, after closing at $2.04 Wednesday on the Nasdaq.

The company said the drug was effective in inhibiting the rate of tumor growth by the third week of the study in animals treated with the drug, compared to those with untreated tumors.

Data from the study also showed the drug HE3235 induces apoptosis, or cell death, in prostate cancer tumor cells. This shows that the drug is effective in part due to its ability to kill tumor cells, Hollis-Eden said in a statement.

The company plans to file an Investigational New Drug application with the U.S. Food and Drug Administration in the first quarter of 2008.

(Reporting by Niveditha Ravi in Bangalore)

((Editing by Amitha Rajan; Reuters Messaging: niveditha.ravi.reuters.com@reuters.net; within U.S +1 646 223 8780; outside U.S. +91 80 4135 5800)) Keywords: HOLLISEDEN STUDY/

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