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A boy cries as he recuperates after surgery during "Operation Smile" at a hospital in Manila's Makati financial district October 26, 2009. Operation Smile aim to provide free surgery for about a hundred children inflicted with cleft lips, cleft palates, and other facial deformities over a period of five days in Makati. REUTERS/Cheryl Ravelo

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    Anti-obesity product safe in mid-stage study

    NEW YORK
    Thu Jul 9, 2009 7:36pm EDT

    NEW YORK (Reuters) - Amylin Pharmaceuticals Inc said on Thursday a mid-stage study of its combination obesity product involving versions of hormones linked to appetite and metabolism yielded positive results.

    Health

    The Phase 2, 28-week study randomized 608 overweight or obese patients to either placebo or various doses of the product, which contains the compounds pramlintide and metreleptin.

    Patients with a body mass index of less than 35 treated with the highest dose experienced significantly more weight loss -- 11 percent on average compared with 1.8 percent for those on placebo.

    The combination therapy had no suggestion of side effects involving the heart or brain -- issues that have doomed other potential obesity treatments.

    Amylin said the results confirm previous mid-stage results with the combination product and "provide a solid foundation for the company's ongoing obesity development program."
    Health


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