Japan finds first case of H1N1 resistant to Tamiflu

By Yoko Kubota

TOKYO (Reuters) - Japan has confirmed its first case of a genetic mutation of the new H1N1 flu virus that shows resistance to Tamiflu, the main antiviral flu drug, a health ministry official said on Thursday.

But they said the mutated virus does not appear to be spreading and they see no immediate threat to public health.

They found the drug-resistant virus in a patient who was given Tamiflu to prevent infection but who developed symptoms anyway, the health ministry's Takeshi Enami said.

The World Health Organization has declared a pandemic is under way from the virus, known as swine flu.

One of the biggest fears is that it will change into a form that resists the effects of the two main antiviral drugs, Tamiflu, made by Switzerland's Roche AG and GlaxoSmithkline's Relenza.

Seasonal flu is no longer affected by older flu drugs and certain strains resist Tamiflu's effects, leaving doctors with fewer options for protecting the most vulnerable patients.

Enami said it was not clear if Tamiflu would have helped the patient, whose age and sex were not given.