(Adds detail, adds shares)
May 14 Isis Pharmaceuticals Inc said
its experimental type 2 diabetes drug reduced blood-sugar levels
in patients in a mid-stage study, sending its shares up as much
as 13 percent before the bell.
The study was testing two doses of the drug in 75 patients
with type 2 diabetes with uncontrolled blood sugar despite
standard treatment, the drugmaker said.
The drug works by interfering at the genetic level to
prevent the formation of disease-causing proteins. Isis is also
evaluating two other drugs to treat type 2 diabetes that use the
Type 2 diabetes, the most common form of the disease, is
closely linked with obesity. It occurs when the body does not
use insulin properly, leading to high blood sugar levels. The
hormone insulin allows the body to use glucose and produce
Isis's drug, ISIS-GCGRRx, works by blocking glucagon, a
hormone produced in the pancreas that opposes the action of
An estimated 382 million people worldwide have diabetes,
according to the International Diabetes Federation, with type 2
accounting for 90-95 percent of all cases.
Isis is also developing drugs for conditions such as spinal
muscular atrophy, blood clotting disorders and cancer.
The Carlsbad, California-based company's were trading at
$28.35 before the bell. They closed at $25.09 on the Nasdaq on
(Reporting by Natalie Grover in Bangalore; Editing by Don
Sebastian and Saumyadeb Chakrabarty)