PREVIEW-Novartis stars among European cancer drug hopes

Wed May 14, 2008 5:18am EDT
 
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* Data on cancer drugs from European companies

* Includes Novartis, Merck MGaA, Roche, Glaxo

* Some data available Friday, May 16, 0100 GMT, ahead of May

30 meeting of American Society of Clinical Oncology (ASCO)

By Sam Cage

ZURICH, May 14 (Reuters) - Investors will assess clinical data this week on cancer drugs from several European companies, who are increasingly keen to develop their oncology portfolios as fierce generic competition erodes business in other areas.

Swiss-based Novartis AG (NOVN.VX) will present two sets of kidney cancer data on RAD001, seen as one of its most important new drugs, at the American Society of Clinical Oncology (ASCO) annual meeting, which starts May 30 in Chicago.

Data on RAD001 -- and other important drugs from European companies, including Roche Holding AG (ROG.VX) and Merck KGaA (MRCG.DE) -- will be presented at the ASCO meeting, but much of the information will be available from early on Friday.

Cancer drugs are a popular target for drugmakers, as they are less vulnerable to competition than other franchises and tend to command higher prices, and RAD001 could be a possible billion-dollar seller.

Novartis will present data from two trials, the most important a Phase II study in combination with Avastin from Genentech Inc DNA.N and Roche.

Novartis will also present more detail at ASCO from a late-stage trial of RAD001, which works by blocking a protein known as mTOR and hence disrupting the growth, division and metabolism of cancer cells. Headline data from that study has already been reported.

The company aims for first approval filings in kidney cancer later this year and will subsequently develop the drug for larger indications such as breast and lung cancers.

"RAD001 might be a very exciting drug but with filings for major indications only in 2011 or later, we have limited sales in our short- and mid-term forecasts," said Landsbanki Kepler analyst Denise Anderson.

AVASTIN THREAT  Continued...

 
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