Research and Markets: Competitor Analysis: FGF-R Agonists and Antagonist - A Compilation of Current Active Projects in Research and Development of Molecules Targeting FGF

DUBLIN--(Business Wire)--
Research and Markets
(http://www.researchandmarkets.com/research/df556b/competitor_analysi) has
announced the addition of the "Competitor Analysis: FGF-R Agonists and
Antagonists" report to their offering.

The present Competitive Intelligence Report about FGF-R agonists and antagonists
provides a competitor evaluation in the field of fibroblast growth factor
receptor (FGF-R) or PDGF targeting molecules for wound healing, cardiac tissue
repair, bone formation or treatment of cancer as of November 2009. Purchase of
the downloadable pdf report includes a 6-month online access to the data of the
report and any updates since the publication date. Credentials to access the
database will be sent by e-mail and allow online work with the project data to
print or export an individual report.

The family of fibroblast growth factors (FGFs) regulates a plethora of
developmental processes, including brain patterning, branching morphogenesis and
limb development. The fibroblast growth factor receptors consist of an
extracellular ligand domain composed of three immunoglobulin-like domains, a
single transmembrane helix domain, and an intracellular domain with tyrosine
kinase activity. These receptors bind fibroblast growth factors, members of the
largest family of growth factor ligands, comprising 22 members.

FGF/FGFR signalling is important in tumour angiogenesis but studies in the last
few years have uncovered increasing evidence that FGFRs are driving oncogenes in
certain cancers and act in a cell autonomous fashion to maintain the malignant
properties of tumour cells. These observations make FGFRs increasingly
attractive as targets for therapeutic intervention in cancer. There is a range
of therapeutic strategies currently employed or in development to antagonise
de-regulated FGFRs including antibodies and small molecule tyrosine kinase
inhibitors.

Quite a number of FGF-R agonists are in development or even marketed in a range
of different indications of tissue repair:

Cardiovascular Diseases:

Fibroblast growth factor-2 (FGF-2 has been shown over the years to exert acute
and direct pro-survival effects, irrespectively of whether it is administered
before, during or after an ischemic insult to the heart. FGF-2 is also a potent
angiogenic protein and a crucial agent for the proliferation, expansion, and
survival of several cell types including those with stem cell properties. Human
clinical trials have pointed to a good safety record for this protein.

Wound Healing:

Wound healing is an evolutionarily conserved, complex, multicellular process
that, in skin, aims at barrier restoration. This complex process is executed and
regulated by an equally complex signaling network involving numerous growth
factors, cytokines and chemokines. Of particular importance is the epidermal
growth factor (EGF) family, transforming growth factor beta (TGF-beta) family,
fibroblast growth factor (FGF) family, vascular endothelial growth factor
(VEGF), granulocyte macrophage colony stimulating factor (GM-CSF),
platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF),
interleukin (IL) family, and tumor necrosis factor-alpha family. Currently,
patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.

Dental and Bone Tissue Repair:

The role of growth factors (GF) in bone repair is widely recognised,
particularly for bone morphogenetic proteins (BMPs), fibroblast growth factor
(FGF), insulin-like growth factors (IGFs), platelet-derived growth factor
(PDGF), transforming growth factor-beta (TGF-beta) and vascular endothelial
growth factor (VEGF). GF are usually stored in the extracellular matrix (ECM),
but after injury are actively released by ECM, cells and platelets.

The report includes a compilation of current active projects in research and
development of molecules targeting FGF or the FGF receptor. In addition, the
report lists company-specific R&D pipelines of FGF /-R targeting small
molecules, antibodies, proteins, peptides, medical devices and DNA. Competitor
projects are listed in a tabular format providing information on:

* Drug Codes,
* Target / Mechanism of Action,
* Class of Compound,
* Company,
* Product Category,
* Indication,
* R&D Stage and
* additional comments with a hyperlink leading to the source of information.

Key Topics Covered:

* FGF-R Agonists in Cardiovascular Diseases
* FGF-R Agonists in Dermatology
* FGF-R Agonists in Metabolic Diseases
* FGF-R Agonists in Nervous System Disease
* FGF-R Agonists in Orthopedic and Dental Diseases
* Biologics as FGF /-R Antagonists
* Selective FGF Receptor tk Inhibitors
* Dual VEGF-R and FGF-R tk Inhibitors
* Triple VEGF-R, PDGF-R and FGF-R tk Inhibitors
* Multi-Target FGF-R tk Inhibitors
* Corporate FGF-R Agonist and Antagonist R&D Pipelines
* About La Merie

Corporate PDGF-R Agonist and Antagonist R&D Pipelines:

* AB Science
* Accelera
* ACT Biotech
* Advenchen Laboratories
* Ambrx
* Amgen
* Ariad Pharmaceuticals
* ArQule
* Astex Therapeutics
* Attenuon
* Aveo Pharmaceuticals
* Auckland UniServices
* Bayer Schering Pharma
* Beijing Pharmaceutical Co
* Biovitrum
* Boehringer Ingelheim
* Bristol-Myers Squibb
* CardioVascular BioTherapeutics
* Cardium Therapeutics
* Eisai
* Eli Lilly
* EntreMed
* Ethical Oncology Sciences
* Exelixis
* Five Point Therapeutics
* Galaxy Biotech
* Genesys Research
* Hanmi Pharmaceutical Co
* Janssen Pharmaceutica
* Kaken Pharmaceutical Co
* Merck & Co
* Merck Serono
* NeuroBiological Technologies
* Novartis
* Phage Biotech
* Sanofi-Aventis
* SinoBiomed
* Taiho Pharmaceutical Co
* Tornier

For more information visit
http://www.researchandmarkets.com/research/df556b/competitor_analysi

Research and Markets
Laura Wood, Senior Manager
press@researchandmarkets.com
U.S. Fax: 646-607-1907
Fax (outside U.S.): +353-1-481-1716

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