Research and Markets: Human Drug Metabolism: An Introduction

DUBLIN--(Business Wire)--
Research and Markets
(http://www.researchandmarkets.com/research/7a9e9d/human_drug_metabol) has
announced the addition of John Wiley and Sons Ltd's new report "Human Drug
Metabolism: An Introduction" to their offering.

There is a gap in the market for a concise, basic drug metabolism textbook that
is written at an accessible level for the broad range of students who take this
course, especially vocational medical and dental students. Drug metabolism
textbooks currently available are too detailed and provide few clinical examples
to engage student interest.

Drug metabolism is a core area of pharmacology. Before any drug can be licensed
it is essential to know how the body metabolises the drug, and the short and
long-term effects it has on the body. It is an area of rapid advancement, which
brings together the fields of pharmacy, pharmacology and medicine. This new text
provides a concise, user-friendly introduction to drug metabolism that is ideal
for undergraduates. Focusing on a conceptual understanding of the drug
metabolism system, the book illustrates the basic mechanisms on how xenobiotics
are detected, chemically modified and then eliminated from human systems.

Reviews:

* "a useful introductory text for the intended audience of students studying
pharmacology and toxicology" (Veterinary Pathology, November 2006)
* "The author has certainly achieved his goal of providing an accessible
introduction to human drug metabolism." (The Annals of Pharmacotherapy, June
2006)
* " for many who are just beginning to learn about drug metabolism because it
deals with all of the relevant aspects." (Journal of Medicinal Chemistry, Vol.
49, No. 8, May 2006)
* "Armed with the knowledge contained in this book, we should all be well on the
way" (Pharmaceutical Physician, May 2006)
* "useful for many who are just beginning to learn about drug metabolisma good
addition to many personal and school libraries." (Journal of Medicinal
Chemistry, April 20, 2006)
* "...thumbs up for ambition." (Chemistry World, 1st March 2006)
* "Overall this is an interesting book that provides a rather comprehensive
overview of drug metabolism in humans" (Journal of Medicinal Chemistry, 2006
Volume 49. No 8)

Key Topics Covered:

* INTRODUCTION.
* DRUG BIOTRANSFORMATIONAL SYSTEMS - ORIGINS AND AIMS.
* HOW PHASE I SYSTEMS METABOLISE SUBSTRATES.
* INDUCTION OF PHASE I SYSTEMS.
* PHASE I ENZYME INHIBITION.
* PHASE II and III PROCESSES.
* FACTORS AFFECTING DRUG METABOLISM. 7.1 Introduction.
* ROLE OF METABOLISM IN DRUG TOXICITY. 8.1 Adverse Drug Reactions.
* APPENDIX A - METHODS IN DRUG METABOLISM.
* APPENDIX B - METABOLISM OF MAJOR ILLICIT DRUGS. B.1 Introduction.
* APPENDIX C - EXAMINATION TECHNIQUES.
* APPENDIX D - SUMMARY OF MAJOR CYP ISOFORMS AND THEIR SUBSTRATES, INHIBITORS
AND INDUCERS. SUGGESTED FURTHER READING.

Author:

Michael D. Coleman, DSc is a Senior Lecturer in Toxicology at Aston University.
His award of the degree of Doctor of Science from Aston University in 2005
reflects his substantial and original contribution to knowledge of Biochemical
Pharmacology and Toxicology of Antiparasitic Drugs.

For more information visit
http://www.researchandmarkets.com/research/7a9e9d/human_drug_metabol

Research and Markets
Laura Wood, Senior Manager
U.S. Fax: 646-607-1907
Fax (outside U.S.): +353-1-481-1716
press@researchandmarkets.com

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