MultiVu Video Feed: National Institutes of Health Study Finds a Decade Later Lifestyle Changes or Metformin Still Lower Type 2 Diabetes Risk

MultiVu Video Feed: National Institutes of Health Study Finds a Decade Later
Lifestyle Changes or Metformin Still Lower Type 2 Diabetes Risk
**EMBARGOED UNTIL WEDNESDAY, OCTOBER 28, 6:30 PM ET**

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NEWS: Benefits of Lifestyle Changes or Metformin Treatment Persist After 10
years in People at High Risk for Type 2 Diabetes

FORMAT: B-roll and Soundbites

ADDITIONAL RESOURCES: Video, hard copy requests, downloadable MPEG2, contact
information and more available at
http://multivu.prnewswire.com/broadcast/36430/press.html

STORY SUMMARY:
About 24 million people in the United States have diabetes. It is the main
cause of kidney failure, limb amputations, and new onset blindness in adults
and a major cause of heart disease and stroke. Type 2 diabetes, which accounts
for up to 95 percent of all diabetes cases, becomes more common with
increasing age. The prevalence of diagnosed diabetes has more than doubled in
the last 30 years, due in large part to the upsurge in obesity.

After following participants in the Diabetes Prevention Program Outcomes Study
(DPPOS) for 10 years, researchers conclude that intensive lifestyle changes
aimed at modest weight loss reduced the rate of developing type 2 diabetes by
34 percent compared with placebo in people at high risk for the disease.
Participants randomly assigned to make lifestyle changes also had more
favorable cardiovascular risk factors, including lower blood pressure and
triglyceride levels, despite taking fewer drugs to control their heart disease
risk. Treatment with the oral diabetes drug metformin reduced the rate of
developing diabetes by 18 percent after 10 years compared with placebo.
Results of the study appear online in The Lancet on October 29, 2009.

Other studies have shown that diet and exercise delay type 2 diabetes in
at-risk people. However, this study, a continuation of the Diabetes Prevention
Program, is the first major trial to show that lifestyle changes can
effectively delay diabetes in a diverse population of overweight American
adults at high risk of diabetes. The study was conducted at 27 medical
centers nationwide (www.bsc.gwu.edu/dpp/clinics.htmlvdoc).

[Credentialed reporters may access the embargoed NIH news release at
www.eurekalert.org.]

SOUNDBITES:
-- Dr. David M. Nathan - Chair, Diabetes Prevention Program Outcomes
Study;
Director, Diabetes Center, Massachusetts General Hospital; and
Professor
of Medicine at Harvard Medical School
-- Dr. Griffin P. Rodgers - Director, National Institute of Diabetes and
Digestive and Kidney Diseases, National Institutes of Health, part of
the U.S. Dept. of Health and Human Services

-- Study Participants

B-ROLL INCLUDES: Exteriors and Interiors of NIH** Dr. Rodgers and Dr. Nathan
at work**Study participants (e.g., preparing food, eating, exercising,
checking weight, meeting with staff at a study center, and handling
medication)**People walking

VIDEO PROVIDED BY: National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of Health, part of the U.S. Dept. of Health and
Human Services

FOR TECHNICAL INFORMATION OR HARD COPY, PLEASE CALL:
MultiVu Media Relations, 800-653-5313 EXT. 3

/PRNewswire -- Oct. 28/

SOURCE National Institute of Diabetes and Digestive and Kidney Diseases,
National Institutes of Health, part of the U.S. Dept. of Health and Human
Services