Aaron Rodgers and the Green Bay Packers sliced up the Washington Redskins' defense while new dad Joe Flacco led the reigning Super Bowl champion Baltimore Ravens to a hard-fought win against the Cleveland Browns on Sunday.
Rodgers soared to a career-high 480 yards passing and four touchdowns and running back James Starks added 132 yards and a touchdown rushing as the Packers dominated the visiting Redskins 38-20, leading 31-0 at one point.
Washington quarterback Robert Griffin III completed 26 of 40 passes for 320 yards and three touchdowns.
Meanwhile, Flacco and his wife welcomed a baby boy just hours before the game and the quarterback quickly returned to work, throwing for 211 yards and a score in the 14-6 home triumph.
Baltimore's defense came up big and knocked out Cleveland quarterback Brandon Weeden in the fourth quarter when he left with a thumb injury. The defense also sacked Weeden five times.
Thrilling finishes marked Week Two of the National Football League season as teams battled until the final seconds and the Houston Texans needed overtime to defeat the Tennessee Titans 30-24.
Matt Schaub tossed a three-yard touchdown to rookie DeAndre Hopkins for the winning score.
Schaub threw for 298 yards and three touchdowns. He led an 87-yard drive at the end of the fourth quarter to tie the score and overcome a stiff challenge from the Titans.
In Kansas City, the Chiefs beat the Dallas Cowboys 17-16 and improve to 2-0 under new coach Andy Reid.
Alex Smith tossed for two scores and the Chiefs defense forced a pair third-quarter fumbles against Dallas and Tony Romo who threw for 298 yards and got 141 receiving yards and a score from Dez Bryant.
In Philadelphia, Nick Novack kicked a 46-yard field goal with seven seconds left as the San Diego Chargers took a 33-30 shootout win over the Eagles.
The Eagles had tied the score about a minute and a half earlier, but Philip Rivers got the final say against Michael Vick, finishing with 419 yards passing and three scores to Vick's 428 and three total TDs, two of them passing.
In Chicago, Jay Cutler tossed a 16-yarder to tight end Martellus Bennett with 10 seconds remaining in the game to help give the Bears a 31-30 victory over the Minnesota Vikings.
Cutler threw for three scores to overcome a pair of interceptions and a fumble, and the Bears drove the field after falling behind 30-24 with about three minutes left.
In Atlanta, Matt Ryan threw two touchdowns and offseason pickup Osi Umenyiora returned his first career interception for a touchdown in the Falcons' 31-24 win over the St. Louis Rams.
Receiver Julio Jones had 11 catches for 182 yards and a score, but Falcons running back Steven Jackson left the game with a thigh injury in the first quarter.
In Indianapolis, Ryan Tannehill passed for 319 yards to help the Miami Dolphins defeat the Indianapolis Colts 24-20.
Colts quarterback Andrew Luck threw for 321 yards, but his final drive stalled at the Dolphins' 23 yard-line in the rare home loss.
In Buffalo, E.J. Manuel's two-yard touchdown pass to Stevie Johnson with two seconds left enabled the Buffalo Bills to defeat the Carolina Panthers 24-23.
In Houston, Matt Schaub tossed a three-yard touchdown to rookie DeAndre Hopkins and the Houston Texans survived a 30-24 overtime thriller against the Tennessee Titans.
Schaub threw for 298 yards and led an 87-yard drive at the end of the fourth quarter to tie the game and overcome a stiff challenge from the Titans.
(Reporting by Jahmal Corner in Seattle, Editing by Gene Cherry)