WASHINGTON Dec 12 Attorneys general from 28
U.S. states have asked the Food and Drug Administration to
reconsider its approval of the powerful painkiller Zohydro ER,
which Kentucky's top law enforcement official said could start
an epidemic of abuse.
The drug, manufactured by Zogenix Inc of San Diego,
was approved by the FDA in October.
In December 2012 a panel of outside experts convened by the
agency had voted 11-2 against the drug's approval, citing its
potential to cause addiction.
Kentucky Attorney General Jack Conway said his state had
been hurt by abuse of prescription painkillers, especially
OxyContin, and he feared more problems with Zohydro ER.
"The approval of this very potent drug is troubling because,
unlike extended-release opioids containing abuse-deterrent
properties, there is nothing that would prevent someone from
easily crushing or injecting Zohydro ER to get high," Conway
Conway joined attorneys general from 27 states and the U.S.
territory of Guam in signing a letter to FDA Commissioner
Margaret Hamburg, dated Tuesday, asking that approval of Zohydro
be reconsidered or that the drug be reformulated with chemical
deterrents to abuse.
"State attorneys general do not want a repeat of the recent
past when potent prescription painkilling drugs entered the
market without abuse-deterrent qualities and without clear
guidance on how they were to be prescribed," the letter said.
The attorneys general said Zohydro reportedly is five to 10
times more potent than standard hydrocodone products.
The FDA approved the drug for daily, long-term treatment for
which other options were inadequate. FDA spokeswoman Morgan
Liscinsky said the agency would review the attorneys generals'
letter and respond.
Abuse of OxyContin became so widespread that manufacturer
Purdue Pharma changed its formula in 2010 so that the drug could
not be injected or snorted as easily.
Zogenix closed at $3.02 in U.S. trading on Thursday, up 0.6