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Medicinova Inc announces positive results in NASH Mouse Model with MN-001 and prepares to initiate phase 2 trial in the U.S.

Tuesday, 14 Jan 2014 08:00am EST 

Medicinova Inc:Says it has announced positive results from a study that examined the potential clinical efficacy of MN-001 for the treatment of NASH (nonalcoholic steatohepatitis).Says MN-001 administered orally once daily (10, 30, and 100 mg/kg) for 3 weeks, was evaluated in the STAM mouse model of nonalcoholic steatohepatitis, as measured by liver biochemistry and histopathology, NAFLD activity score (NAS), and percent of fibrosis and gene expression.Says MN-001, in a dose-dependent manner, significantly reduced fibrosis area compared with vehicle (p <0.01) as demonstrated by a reduction in liver hydroxyproline content, supporting MN-001's anti-fibrotic properties. 

Company Quote

15.0 +4.64%
18 Sep 2014