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Ablynx NV to Present Pre-Clinical Proof-of-Concept Data on ALX-0761 at ACR

Monday, 28 Oct 2013 02:30am EDT 

Ablynx NV announced that pre-clinical proof-of-concept data from ALX-0761, a Nanobody partnered with Merck Serono, will be presented at the Annual Meeting of the American College of Rheumatology (ACR), 26 to 30 October 2013, San Diego, California. The poster presentation will include data from in vivo experiments that assessed the efficacy of ALX-0761 in a cynomolgus monkey model that mimics human rheumatoid arthritis. In addition, total target levels of both IL-17A and IL-17F, pharmacodynamic biomarkers, immunogenicity and drug exposure were analyzed. The proof-of-concept results demonstrated that both IL-17A and IL-17F play a role in the onset and/or maintenance of rheumatoid arthritis and that ALX-0761 improved the clinical endpoints: X-ray score B (the score for bone erosion or architectural joint destruction accompanied by bone erosion) and the arthritis score (the total of the swelling scores of the individual joints). Furthermore, promising biomarkers were identified to aid further clinical development.