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Ipsen SA and Active Biotech AB Present Tasquinimod Biomarker Phase II Data at ESMO 2012

Monday, 1 Oct 2012 02:30am EDT 

Ipsen SA announced that, along with Active Biotech AB, it presented a new set of data on biomarkers from the previously concluded tasquinimod Phase II study in chemotherapy-na├»ve metastatic castrate resistant prostate cancer (CRPC) at the scientific congress ESMO (European Society for Medical Oncology) held in Vienna September 28, 2012-October 2, 2012. The purpose of this analysis from the phase II trial was to investigate the effects of tasquinimod on selected biomarkers to confirm preclinical findings on the mechanism of action. The results support an effect of tasquinimod on both immunomodulation and angiogenesis which positions tasquinimod as a therapeutic approach with a mechanism of action that does not target the androgen receptor pathway. The findings shall be further validated in the ongoing phase III placebo-controlled study in men with bone-metastatic CRPC, which has been adequately powered to detect an OS improvement. 

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