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Amarantus Biosciences Inc Announces Positive Efficacy Data For MANF In Nigral Delivery Neurorestoration Animal Model Of Parkinson's Disease


Wednesday, 9 Jan 2013 08:31am EST 

Amarantus Biosciences Inc announced positive preclinical efficacy data for MANF in a neurorestoration 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. The data demonstrate that unlike Glial cell-Derived Neurotrophic Factor (GDNF), MANF significantly reduces behavioral deficits, increases dopaminergic (DA) nerve terminal reinnervation of the striatum, and increases dopamine concentrations in the striatum when MANF is administered directly to the substantia nigra (SNc). The data produced comparing optimal doses to the SNc of MANF = 10 ug and GDNF = 10 ug in this model indicate the following at four weeks post-treatment: 1MANF reduced behavioral deficits by 53%, whereas behavioral deficits with GDNF increased by 20%; 2MANF produced a 14.4% reinnervation of the striatum, whereas striatum innervation with GDNF was reduced by 9.9%; 3MANF increased dopamine concentrations in the striatum, whereas striatum dopamine concentrations with GDNF did not increase. 

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21 Nov 2014