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Amgen And AstraZeneca announce positive results from phase 3 study of Brodalumab (AMG 827) in patients with moderate-to-severe plaque psoriasis

Friday, 9 May 2014 04:01pm EDT 

Amgen Inc:Says the company and AstraZeneca announced that the Phase 3 AMAGINE-1TMstudy evaluating brodalumab in patients with moderate-to-severe plaque psoriasis met all primary and secondary endpoints for both evaluated doses.Brodalumab is the only investigational treatment in development that binds to the interleukin-17 (IL-17) receptor and inhibits inflammatory signaling by blocking the binding of several IL-17 ligands to the receptor.Primary endpoints were patients achieving at least a 75 percent improvement from baseline in disease severity at week 12, as measured by the Psoriasis Area Severity Index.Says a significantly higher proportion of patients treated with brodalumab achieved a PASI 75 response (primary endpoint), as well as PASI 90 and PASI 100 responses at week 12 (secondary endpoints) compared to placebo. 

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2.79 +1.74%
26 Dec 2014