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Ariad Pharmaceuticals Inc Announces 12-Month Data From Pivotal PACE Trial Of Ponatinib In Heavily Pretreated Patients

Tuesday, 11 Dec 2012 08:05am EST 

Ariad Pharmaceuticals Inc announced twelve-month follow-up data from the pivotal PACE trial of ponatinib, investigational BCR-ABL inhibitor, in heavily pretreated patients with advanced forms of chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The study now shows that 57% of accelerated-phase CML patients in the trial, including 50% of patients with the T315I mutation, achieved hematologic response (MaHR), the primary end-point for patients with advanced disease in the trial. 

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