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AstraZeneca PLC and Bristol-Myers Announce Results from Phase III Study Evaluating Dapagliflozin in Adult Patients with Type 2 Diabetes

Thursday, 26 Sep 2013 08:00pm EDT 

AstraZeneca PLC and Bristol-Myers Squibb Company announced results from a Phase III study evaluating dapagliflozin in adult patients with type 2 diabetes who were inadequately controlled on combination treatment with metformin plus sulfonylurea. Patients treated with dapagliflozin 10 mg as an add-on therapy to metformin plus sulfonylurea demonstrated significant improvements in glycosylated hemoglobin levels (HbA1c) and, among key secondary endpoints, significant reductions in fasting plasma glucose (FPG) and in body weight compared to placebo at 24 weeks. Significant improvements were also observed in seated systolic blood pressure (SBP) at eight weeks in patients treated with dapagliflozin compared to placebo. The results were presented at the 49th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Barcelona, Spain. 

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