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Celldex Therapeutics Inc's Rindopepimut demonstrates promising clinical activity in patients with EGFRvIII-positive recurrent Glioblastoma

Sunday, 24 Nov 2013 01:25pm EST 

Celldex Therapeutics Inc:Reports interim data from its ongoing, exploratory Phase 2 ReACT study of rindopepimut in recurrent glioblastoma.Says Rindopepimut is an immunotherapeutic vaccine that targets the tumor specific oncogene EGFRvIII(v3).Says patients with EGFRvIII-positive glioblastoma typically have a worse prognosis than the overall glioblastoma population, including poor long term survival.Says the ReACT results demonstrate promising signs of clinical activity in advanced patient populations, including patients both na├»ve and refractory to bevacizumab (Avastin).Says an update on long-term survival for the three completed Phase 2 frontline studies in EGFRvIII-positive glioblastoma was also presented and results continue to exceed outcomes seen in contemporary controls. 

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