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Exelixis, Inc announces positive top line results for phase 3 pivotal trial of cobimetinib in combination with vemurafenib

Monday, 14 Jul 2014 01:00am EDT 

Exelixis, Inc:Announces positive top line results from coBRIM, the phase 3 pivotal trial evaluating cobimetinib, a specific MEK inhibitor discovered by Exelixis.Says it is in combination with vemurafenib in previously untreated patients with unresectable locally advanced or metastatic melanoma harboring the BRAF(V600)mutation.Exelixis' collaborator Genentech, a member of the Roche Group, informed the company that coBRIM met its primary endpoint, delivering a statistically increase in progression-free survival (PFS) for the combination of cobimetinib plus vemurafenib as compared to vemurafenib alone.Adverse events were consistent with those observed in a previous study of the combination. 

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