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GlaxosmithKline Plc and Genmab announce top-line results from Phase III study of ofatumumab versus physicians' choice for bulky fludarabine-refractory CLL

Friday, 27 Jun 2014 02:27pm EDT 

GlaxosmithKline Plc:Says the company and Genmab A/S announced Phase III study of ofatumumab (Arzerra) versus physicians' choice in patients with bulky fludarabine-refractory chronic lymphocytic leukaemia (CLL) did not meet its primary endpoint of progression free survival.Says the median PFS, as assessed by the Independent Review Committee, was 5.36 months for ofatumumab and 3.61 months for physicians' choice (Hazard Ratio 0.79, p=0.267.Study (OMB114242) was conducted to meet the requirements from the EU Commission for the conditional approval of ofatumumab for the treatment of CLL in patients who are refractory to fludarabine and alemtuzumab. 

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24 Oct 2014